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Cox7a2l cytochrome c oxidase subunit 7A2 like [ Mus musculus (house mouse) ]

Gene ID: 20463, updated on 5-Mar-2024

Summary

Official Symbol
Cox7a2lprovided by MGI
Official Full Name
cytochrome c oxidase subunit 7A2 likeprovided by MGI
Primary source
MGI:MGI:106015
See related
Ensembl:ENSMUSG00000024248 AllianceGenome:MGI:106015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EB1; SIG81; Scaf1; COX7AR; COX7RP; SIG-81; Silg81
Summary
Predicted to enable cytochrome-c oxidase activity. Involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrial respirasome. Is expressed in several structures, including alimentary system; facial bone primordium; nervous system; respiratory system; and sensory organ. Orthologous to human COX7A2L (cytochrome c oxidase subunit 7A2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 103.0), heart adult (RPKM 81.6) and 28 other tissues See more
Orthologs
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Genomic context

See Cox7a2l in Genome Data Viewer
Location:
17 E4; 17 53.02 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (83809346..83821762, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (83501917..83514333, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene echinoderm microtubule associated protein like 4 Neighboring gene predicted gene, 46594 Neighboring gene STARR-positive B cell enhancer mm9_chr17:83883255-83883556 Neighboring gene predicted gene, 53223 Neighboring gene STARR-seq mESC enhancer starr_43378 Neighboring gene predicted gene, 52292 Neighboring gene STARR-positive B cell enhancer ABC_E2501 Neighboring gene predicted gene, 41635

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Not Applicable (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103208

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial respirasome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial respirasome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial respirasome IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome c oxidase subunit 7A-related protein, mitochondrial
Names
cytochrome c oxidase subunit VIIa polypeptide 2-like
cytochrome c oxidase subunit VIIa-related protein
silica-induced gene 81 protein
supercomplex assembly factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159529.1NP_001153001.1  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK009614, AK133520, BP769290, BY122624
    Consensus CDS
    CCDS50194.1
    UniProtKB/TrEMBL
    E9PZS8, Q3U7R2
    Related
    ENSMUSP00000131584.2, ENSMUST00000167741.9
    Conserved Domains (1) summary
    cd00928
    Location:55130
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
  2. NM_009187.3NP_033213.1  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_033213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK133520, BP769290, BY122624
    Consensus CDS
    CCDS28995.1
    UniProtKB/Swiss-Prot
    Q61387
    UniProtKB/TrEMBL
    Q3U7R2, Q3UDK5
    Related
    ENSMUSP00000025095.8, ENSMUST00000025095.9
    Conserved Domains (1) summary
    cd00928
    Location:55107
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    83809346..83821762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)