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EPHA8 EPH receptor A8 [ Homo sapiens (human) ]

Gene ID: 2046, updated on 15-Jun-2019

Summary

Official Symbol
EPHA8provided by HGNC
Official Full Name
EPH receptor A8provided by HGNC
Primary source
HGNC:HGNC:3391
See related
Ensembl:ENSG00000070886 MIM:176945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EEK; EK3; HEK3
Summary
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See EPHA8 in Genome Data Viewer
Location:
1p36.12
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (22563502..22603594)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (22890004..22930087)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376856 Neighboring gene zinc finger and BTB domain containing 40 Neighboring gene microRNA 6127 Neighboring gene complement C1q A chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHA forward signaling, organism-specific biosystem
    EPHA forward signaling
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
  • EphrinA-EPHA pathway, organism-specific biosystem (from Pathway Interaction Database)
    EphrinA-EPHA pathway, organism-specific biosystem
    EphrinA-EPHA pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GPI-linked ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to follicle-stimulating hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
substrate-dependent cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin type-A receptor 8
Names
EPH- and ELK-related kinase
EPH- and ELK-related tyrosine kinase
EPH-like kinase 3
hydroxyaryl-protein kinase
protein-tyrosine kinase
tyrosine-protein kinase receptor EEK
tyrosylprotein kinase
NP_001006944.1
NP_065387.1
XP_011539271.1
XP_011539272.1
XP_011539274.1
XP_011539275.1
XP_011539277.1
XP_024309660.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006943.3NP_001006944.1  ephrin type-A receptor 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001006944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1. This transcript is supported by mRNA transcripts but the predicted ORF and its predicted precursor sequence have not yet been experimentally confirmed.
    Source sequence(s)
    AL035703, BC072417, DR007053
    Consensus CDS
    CCDS30626.1
    UniProtKB/Swiss-Prot
    P29322
    Related
    ENSP00000363775.4, ENST00000374644.8
    Conserved Domains (2) summary
    pfam00041
    Location:330418
    fn3; Fibronectin type III domain
    cl02704
    Location:31203
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  2. NM_020526.5NP_065387.1  ephrin type-A receptor 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_065387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB040892, AL035703, BC072417, DR007053
    Consensus CDS
    CCDS225.1
    UniProtKB/Swiss-Prot
    P29322
    Related
    ENSP00000166244.3, ENST00000166244.8
    Conserved Domains (8) summary
    cd09550
    Location:933995
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    smart00454
    Location:934994
    SAM; Sterile alpha motif
    cd00063
    Location:440531
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:630896
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:330423
    fn3; Fibronectin type III domain
    pfam07714
    Location:635892
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:566630
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:31203
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    22563489..22603595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540969.1XP_011539271.1  ephrin type-A receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_011539271.1

    Conserved Domains (8) summary
    cd09550
    Location:858920
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    smart00454
    Location:859919
    SAM; Sterile alpha motif
    cd00063
    Location:365456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:555821
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:255348
    fn3; Fibronectin type III domain
    pfam07714
    Location:560817
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:491555
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1128
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  2. XM_011540972.1XP_011539274.1  ephrin type-A receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_011539274.1

    Conserved Domains (8) summary
    cd09550
    Location:858920
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    smart00454
    Location:859919
    SAM; Sterile alpha motif
    cd00063
    Location:365456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:555821
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:255348
    fn3; Fibronectin type III domain
    pfam07714
    Location:560817
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:491555
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1128
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  3. XM_011540970.1XP_011539272.1  ephrin type-A receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_011539272.1

    Conserved Domains (8) summary
    cd09550
    Location:858920
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    smart00454
    Location:859919
    SAM; Sterile alpha motif
    cd00063
    Location:365456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:555821
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:255348
    fn3; Fibronectin type III domain
    pfam07714
    Location:560817
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:491555
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1128
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  4. XM_011540973.1XP_011539275.1  ephrin type-A receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_011539275.1

    Conserved Domains (8) summary
    cd09550
    Location:858920
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    smart00454
    Location:859919
    SAM; Sterile alpha motif
    cd00063
    Location:365456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:555821
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:255348
    fn3; Fibronectin type III domain
    pfam07714
    Location:560817
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:491555
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1128
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  5. XM_024453892.1XP_024309660.1  ephrin type-A receptor 8 isoform X2

    Conserved Domains (4) summary
    cd09550
    Location:528590
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    cd05066
    Location:225491
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:34119
    fn3; Fibronectin type III domain
    pfam14575
    Location:161225
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  6. XM_011540975.3XP_011539277.1  ephrin type-A receptor 8 isoform X2

    Conserved Domains (4) summary
    cd09550
    Location:528590
    SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors
    cd05066
    Location:225491
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:34119
    fn3; Fibronectin type III domain
    pfam14575
    Location:161225
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RNA

  1. XR_946576.2 RNA Sequence

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