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St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20440, updated on 11-Apr-2024

Summary

Official Symbol
St6gal1provided by MGI
Official Full Name
beta galactoside alpha 2,6 sialyltransferase 1provided by MGI
Primary source
MGI:MGI:108470
See related
Ensembl:ENSMUSG00000022885 AllianceGenome:MGI:108470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat1; St6gal; St6galI; St6Gal-I
Summary
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]
Expression
Broad expression in genital fat pad adult (RPKM 48.2), liver E18 (RPKM 29.4) and 22 other tissues See more
Orthologs
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Genomic context

Location:
16 B1; 16 14.03 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (23043478..23179100)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23224729..23360350)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23181839-23182022 Neighboring gene predicted pseudogene 6630 Neighboring gene predicted gene 15746 Neighboring gene STARR-positive B cell enhancer ABC_E5533 Neighboring gene cDNA sequence BC106179 Neighboring gene predicted gene, 53940 Neighboring gene STARR-positive B cell enhancer ABC_E1184 Neighboring gene STARR-positive B cell enhancer ABC_E11608 Neighboring gene STARR-positive B cell enhancer ABC_E4161 Neighboring gene predicted gene, 30814 Neighboring gene STARR-seq mESC enhancer starr_40438 Neighboring gene STARR-seq mESC enhancer starr_40440 Neighboring gene STARR-seq mESC enhancer starr_40441 Neighboring gene receptor transporter protein 1 Neighboring gene MBL associated serine protease 1 Neighboring gene STARR-seq mESC enhancer starr_40442 Neighboring gene VISTA enhancer mm1315 Neighboring gene 60S ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC116663

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi trans cisterna ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 1
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
ST6Gal I
alpha 2,6-ST 1
NP_001239434.1
NP_001239435.1
NP_001413535.1
NP_666045.1
XP_006521938.1
XP_006521939.1
XP_011244150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252505.1NP_001239434.1  beta-galactoside alpha-2,6-sialyltransferase 1

    See identical proteins and their annotated locations for NP_001239434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK034768, BY254258, CD349601, CF741963, CJ238175, CN458528
    Consensus CDS
    CCDS28077.1
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Related
    ENSMUSP00000136206.2, ENSMUST00000178797.8
    Conserved Domains (1) summary
    pfam00777
    Location:174379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001252506.1NP_001239435.1  beta-galactoside alpha-2,6-sialyltransferase 1

    See identical proteins and their annotated locations for NP_001239435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI787561, AK034768, BY134193, CF741963, CJ238175, CN458528
    Consensus CDS
    CCDS28077.1
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Related
    ENSMUSP00000110992.2, ENSMUST00000115335.2
    Conserved Domains (1) summary
    pfam00777
    Location:174379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001426606.1NP_001413535.1  beta-galactoside alpha-2,6-sialyltransferase 1

    Status: REVIEWED

    Source sequence(s)
    AC163612
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
  4. NM_145933.4NP_666045.1  beta-galactoside alpha-2,6-sialyltransferase 1

    See identical proteins and their annotated locations for NP_666045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC092222, CF898349, CJ238175
    Consensus CDS
    CCDS28077.1
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Related
    ENSMUSP00000023601.8, ENSMUST00000023601.14
    Conserved Domains (1) summary
    pfam00777
    Location:174379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    23043478..23179100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521876.5XP_006521939.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006521939.1

    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Conserved Domains (1) summary
    pfam00777
    Location:174379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_011245848.2XP_011244150.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011244150.1

    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Conserved Domains (1) summary
    pfam00777
    Location:174379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_006521875.4XP_006521938.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006521938.1

    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Conserved Domains (1) summary
    pfam00777
    Location:174379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)