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Siah1a siah E3 ubiquitin protein ligase 1A [ Mus musculus (house mouse) ]

Gene ID: 20437, updated on 8-Feb-2024

Summary

Official Symbol
Siah1aprovided by MGI
Official Full Name
siah E3 ubiquitin protein ligase 1Aprovided by MGI
Primary source
MGI:MGI:108064
See related
Ensembl:ENSMUSG00000036840 AllianceGenome:MGI:108064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sinh1a
Summary
Enables several functions, including disordered domain specific binding activity; protein homodimerization activity; and zinc ion binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within male gamete generation; post-embryonic development; and regulation of growth. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including alimentary system; early embryo; gonad; hemolymphoid system gland; and liver. Orthologous to human SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 8.3), CNS E14 (RPKM 8.0) and 28 other tissues See more
Orthologs
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Genomic context

See Siah1a in Genome Data Viewer
Location:
8 C3; 8 42.1 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87442450..87472634, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86720454..86746006, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family C member 12 Neighboring gene STARR-positive B cell enhancer ABC_E10515 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene predicted gene, 22305 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:89230711-89230912 Neighboring gene STARR-seq mESC enhancer starr_22187 Neighboring gene predicted gene 10638 Neighboring gene STARR-seq mESC enhancer starr_22189 Neighboring gene predicted gene, 39215 Neighboring gene predicted gene, 33877 Neighboring gene NEDD4 binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SIAH1A
Names
RING-type E3 ubiquitin transferase SIAH1A
mSiah-1a
seven in absentia 1A
seven in absentia homolog 1a
siah-1a
NP_033198.1
XP_006530847.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009172.2NP_033198.1  E3 ubiquitin-protein ligase SIAH1A

    See identical proteins and their annotated locations for NP_033198.1

    Status: VALIDATED

    Source sequence(s)
    AA420282, AC142211, BC046317, BE634662
    Consensus CDS
    CCDS22504.1
    UniProtKB/Swiss-Prot
    P61092, Q06985, Q7TPV6
    Related
    ENSMUSP00000044123.5, ENSMUST00000045296.6
    Conserved Domains (2) summary
    cd16751
    Location:3978
    RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins
    pfam03145
    Location:82278
    Sina; Seven in absentia protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    87442450..87472634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530784.5XP_006530847.3  E3 ubiquitin-protein ligase SIAH1A isoform X1

    Conserved Domains (2) summary
    cd16751
    Location:112151
    RING-HC_SIAH1; RING finger, HC subclass, found in seven in absentia homolog 1 (SIAH1) and similar proteins
    pfam03145
    Location:155351
    Sina; Seven in absentia protein family