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Shmt1 serine hydroxymethyltransferase 1 (soluble) [ Mus musculus (house mouse) ]

Gene ID: 20425, updated on 12-Aug-2018

Summary

Official Symbol
Shmt1provided by MGI
Official Full Name
serine hydroxymethyltransferase 1 (soluble)provided by MGI
Primary source
MGI:MGI:98299
See related
Ensembl:ENSMUSG00000020534 Vega:OTTMUSG00000007760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Shmt; mshmt; C81125; mshmt1; mshmt2; AI324848; AI385541
Expression
Broad expression in liver adult (RPKM 76.7), kidney adult (RPKM 33.5) and 15 other tissues See more
Orthologs

Genomic context

See Shmt1 in Genome Data Viewer
Location:
11; 11 B2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (60788886..60811265, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60602399..60624767, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene topoisomerase (DNA) III alpha Neighboring gene Smith-Magenis syndrome chromosome region, candidate 8 homolog (human) Neighboring gene phosphoserine aminotransferase 1 pseudogene Neighboring gene predicted gene 12618 Neighboring gene dehydrogenase/reductase (SDR family) member 7B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
L-allo-threonine aldolase activity ISO
Inferred from Sequence Orthology
more info
 
amino acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cobalt ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine hydroxymethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine hydroxymethyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
mRNA 5'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
serine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
translation repressor activity, mRNA regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation repressor activity, mRNA regulatory element binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-serine catabolic process ISO
Inferred from Sequence Orthology
more info
 
L-serine metabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to leukemia inhibitory factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to tetrahydrofolate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to tetrahydrofolate ISO
Inferred from Sequence Orthology
more info
 
dTMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
folic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
folic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
glycine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
glycine biosynthetic process from serine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine biosynthetic process from serine ISO
Inferred from Sequence Orthology
more info
 
glycine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycine metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
one-carbon metabolic process IC
Inferred by Curator
more info
PubMed 
protein homotetramerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
purine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purine nucleobase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tetrahydrofolate interconversion ISO
Inferred from Sequence Orthology
more info
 
tetrahydrofolate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tetrahydrofolate metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine hydroxymethyltransferase, cytosolic
Names
glycine hydroxymethyltransferase
serine methylase
NP_033197.2
XP_006532707.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009171.2NP_033197.2  serine hydroxymethyltransferase, cytosolic

    See identical proteins and their annotated locations for NP_033197.2

    Status: VALIDATED

    Source sequence(s)
    AI385541, BQ832130, BQ942592, CF159149
    Consensus CDS
    CCDS24799.1
    UniProtKB/Swiss-Prot
    P50431
    Related
    ENSMUSP00000018744.8, OTTMUSP00000008170, ENSMUST00000018744.14, OTTMUST00000017725
    Conserved Domains (2) summary
    PLN03226
    Location:13475
    PLN03226; serine hydroxymethyltransferase; Provisional
    pfam00464
    Location:20419
    SHMT; Serine hydroxymethyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    60788886..60811265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532644.3XP_006532707.1  serine hydroxymethyltransferase, cytosolic isoform X1

    See identical proteins and their annotated locations for XP_006532707.1

    UniProtKB/Swiss-Prot
    P50431
    Related
    ENSMUSP00000134269.1, OTTMUSP00000053871, ENSMUST00000174214.1, OTTMUST00000096422
    Conserved Domains (2) summary
    PLN03226
    Location:13475
    PLN03226; serine hydroxymethyltransferase; Provisional
    pfam00464
    Location:20419
    SHMT; Serine hydroxymethyltransferase
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