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Scg5 secretogranin V [ Mus musculus (house mouse) ]

Gene ID: 20394, updated on 1-Mar-2024

Summary

Official Symbol
Scg5provided by MGI
Official Full Name
secretogranin Vprovided by MGI
Primary source
MGI:MGI:98289
See related
Ensembl:ENSMUSG00000023236 AllianceGenome:MGI:98289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
7B2; Sgne1; Sgne-1
Summary
Enables enzyme inhibitor activity. Involved in intracellular protein transport; peptide hormone processing; and regulation of hormone secretion. Is active in nucleus. Is expressed in several structures, including gut; lung; nervous system; and sensory organ. Used to study pituitary-dependent Cushing's disease. Orthologous to human SCG5 (secretogranin V). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 84.7), cerebellum adult (RPKM 75.9) and 5 other tissues See more
Orthologs
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Genomic context

See Scg5 in Genome Data Viewer
Location:
2 E4; 2 57.45 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113606708..113659423, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (113776313..113829091, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene gremlin 1, DAN family BMP antagonist Neighboring gene predicted gene, 46756 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113664128-113664429 Neighboring gene Rho GTPase activating protein 11A Neighboring gene STARR-seq mESC enhancer starr_05402 Neighboring gene predicted gene, 30985

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide hormone processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neuroendocrine protein 7B2
Names
secretogranin-5
secretory granule endocrine protein I
secretory granule neuroendocrine protein 1, 7B2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420937.1NP_001407866.1  neuroendocrine protein 7B2 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
  2. NM_001420938.1NP_001407867.1  neuroendocrine protein 7B2 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
  3. NM_001420939.1NP_001407868.1  neuroendocrine protein 7B2 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
  4. NM_001420942.1NP_001407871.1  neuroendocrine protein 7B2 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
  5. NM_001420943.1NP_001407872.1  neuroendocrine protein 7B2 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
  6. NM_001420944.1NP_001407873.1  neuroendocrine protein 7B2 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
  7. NM_001420945.1NP_001407874.1  neuroendocrine protein 7B2 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
  8. NM_001420946.1NP_001407875.1  neuroendocrine protein 7B2 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AL772405
  9. NM_001420947.1NP_001407876.1  neuroendocrine protein 7B2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL772405
  10. NM_009162.4NP_033188.3  neuroendocrine protein 7B2 isoform c precursor

    See identical proteins and their annotated locations for NP_033188.3

    Status: VALIDATED

    Source sequence(s)
    AL772405
    Consensus CDS
    CCDS16561.1
    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
    Related
    ENSMUSP00000024005.8, ENSMUST00000024005.8
    Conserved Domains (1) summary
    pfam05281
    Location:24199
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

RNA

  1. NR_185217.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772405
  2. NR_185218.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL772405

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    113606708..113659423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159847.1XP_036015740.1  neuroendocrine protein 7B2 isoform X1

    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
    Conserved Domains (1) summary
    pfam05281
    Location:24199
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
  2. XM_036159851.1XP_036015744.1  neuroendocrine protein 7B2 isoform X1

    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
    Conserved Domains (1) summary
    pfam05281
    Location:24199
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
  3. XM_036159848.1XP_036015741.1  neuroendocrine protein 7B2 isoform X1

    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
    Conserved Domains (1) summary
    pfam05281
    Location:24199
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
  4. XM_036159849.1XP_036015742.1  neuroendocrine protein 7B2 isoform X1

    UniProtKB/Swiss-Prot
    P12961, Q8CCZ3, Q9CYP0, Q9D2P6, Q9DB14
    UniProtKB/TrEMBL
    Q3TT51
    Conserved Domains (1) summary
    pfam05281
    Location:24199
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)