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Srsf3 serine and arginine-rich splicing factor 3 [ Mus musculus (house mouse) ]

Gene ID: 20383, updated on 26-Sep-2022

Summary

Official Symbol
Srsf3provided by MGI
Official Full Name
serine and arginine-rich splicing factor 3provided by MGI
Primary source
MGI:MGI:98285
See related
Ensembl:ENSMUSG00000071172 AllianceGenome:MGI:98285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
X16; Sfrs3
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Broad expression in CNS E11.5 (RPKM 128.5), CNS E14 (RPKM 91.1) and 26 other tissues See more
Orthologs
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Genomic context

See Srsf3 in Genome Data Viewer
Location:
17 A3.3; 17 15.03 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29251634..29262346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29032660..29043372)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 Neighboring gene predicted gene, 23887 Neighboring gene predicted gene 16196 Neighboring gene tumor protein p53 pathway corepressor 1 Neighboring gene predicted gene, 41556 Neighboring gene cyclin-dependent kinase inhibitor 1A (P21)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in insulin receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/arginine-rich splicing factor 3
Names
pre-mRNA-splicing factor SRP20
splicing factor, arginine/serine-rich 3 (SRp20)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013663.5NP_038691.1  serine/arginine-rich splicing factor 3

    See identical proteins and their annotated locations for NP_038691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AK078891, BB008721, BY249648
    Consensus CDS
    CCDS28590.1
    UniProtKB/Swiss-Prot
    P84104, Q564E9
    UniProtKB/TrEMBL
    A0A6P5RD25
    Related
    ENSMUSP00000117045.2, ENSMUST00000130216.3
    Conserved Domains (1) summary
    cd12645
    Location:686
    RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)

RNA

  1. NR_036613.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, compared to variant 1, that has an in-frame stop codon. The resulting predicted ORF is truncated at the 3' end compared to variant 1, rendering the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this transcript is not thought to be protein-coding.
    Source sequence(s)
    AC167363, AK078891, AK152411, BB008721, BY249648
    Related
    ENSMUST00000037776.16

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29251634..29262346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)