Format

Send to:

Choose Destination

Srsf2 serine/arginine-rich splicing factor 2 [ Mus musculus (house mouse) ]

Gene ID: 20382, updated on 12-Aug-2018

Summary

Official Symbol
Srsf2provided by MGI
Official Full Name
serine/arginine-rich splicing factor 2provided by MGI
Primary source
MGI:MGI:98284
See related
Ensembl:ENSMUSG00000034120 Vega:OTTMUSG00000003783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SC35; MRF-1; Pr264; Sfrs2; Sfrs10; D11Wsu175e
Summary
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in ovary adult (RPKM 340.2), thymus adult (RPKM 275.9) and 28 other tissues See more
Orthologs

Genomic context

See Srsf2 in Genome Data Viewer
Location:
11 E2; 11 81.49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (116849897..116853114, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (116711211..116714408, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 6 Neighboring gene methyltransferase like 23 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene mannoside acetylglucosaminyltransferase 5, isoenzyme B Neighboring gene predicted gene, 33829 Neighboring gene uncharacterized LOC102636988

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
pre-mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
interchromatin granule ISO
Inferred from Sequence Orthology
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/arginine-rich splicing factor 2
Names
myelin regulatory factor 1
putative myelin regulatory factor 1
splicing component, 35 kDa
splicing factor Sc35
splicing factor, arginine/serine-rich 2 (SC-35)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011358.2NP_035488.1  serine/arginine-rich splicing factor 2

    See identical proteins and their annotated locations for NP_035488.1

    Status: REVIEWED

    Source sequence(s)
    AK086103, BG093253, CJ043688
    Consensus CDS
    CCDS25680.1
    UniProtKB/Swiss-Prot
    Q62093
    Related
    ENSMUSP00000090059.6, OTTMUSP00000004038, ENSMUST00000092404.12, OTTMUST00000008306
    Conserved Domains (1) summary
    cd12311
    Location:1688
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    116849897..116853114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248835.2XP_011247137.1  serine/arginine-rich splicing factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011247137.1

    UniProtKB/Swiss-Prot
    Q62093
    Conserved Domains (1) summary
    cd12311
    Location:1688
    RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins
Support Center