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Selplg selectin, platelet (p-selectin) ligand [ Mus musculus (house mouse) ]

Gene ID: 20345, updated on 5-Mar-2024

Summary

Official Symbol
Selplgprovided by MGI
Official Full Name
selectin, platelet (p-selectin) ligandprovided by MGI
Primary source
MGI:MGI:106689
See related
Ensembl:ENSMUSG00000048163 AllianceGenome:MGI:106689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD162; Psgl1; Selp1; Selpl; Psgl-1
Summary
Involved in leukocyte adhesive activation. Acts upstream of or within leukocyte tethering or rolling. Predicted to be located in plasma membrane raft and uropod. Predicted to be active in plasma membrane. Is expressed in brain and thymus primordium. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human SELPLG (selectin P ligand). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 159.7), spleen adult (RPKM 93.8) and 7 other tissues See more
Orthologs
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Genomic context

See Selplg in Genome Data Viewer
Location:
5 F; 5 55.59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113955859..113970576, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113817798..113832528, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42004 Neighboring gene STARR-positive B cell enhancer ABC_E3601 Neighboring gene protein LLP homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114275604-114275870 Neighboring gene STARR-positive B cell enhancer ABC_E1686 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114282525-114282873 Neighboring gene STARR-seq mESC enhancer starr_14053 Neighboring gene predicted gene, 52824 Neighboring gene coronin, actin binding protein 1C Neighboring gene predicted gene, 42005

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (6) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte adhesive activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in uropod ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
P-selectin glycoprotein ligand 1
Names
selectin P ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009151.3NP_033177.3  P-selectin glycoprotein ligand 1 precursor

    See identical proteins and their annotated locations for NP_033177.3

    Status: VALIDATED

    Source sequence(s)
    AC159240, BE859840, BG070861, BG083864, BY553294, CJ134610
    Consensus CDS
    CCDS51621.1
    UniProtKB/Swiss-Prot
    Q62170
    UniProtKB/TrEMBL
    Q3TA56
    Related
    ENSMUSP00000098436.5, ENSMUST00000100874.6
    Conserved Domains (1) summary
    PRK10811
    Location:133276
    rne; ribonuclease E; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113955859..113970576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530229.5XP_006530292.1  P-selectin glycoprotein ligand 1 isoform X1

    See identical proteins and their annotated locations for XP_006530292.1

    UniProtKB/Swiss-Prot
    Q62170
    UniProtKB/TrEMBL
    Q3TA56
    Conserved Domains (1) summary
    PRK10811
    Location:133276
    rne; ribonuclease E; Reviewed