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SUSD3 sushi domain containing 3 [ Homo sapiens (human) ]

Gene ID: 203328, updated on 11-Jun-2021

Summary

Official Symbol
SUSD3provided by HGNC
Official Full Name
sushi domain containing 3provided by HGNC
Primary source
HGNC:HGNC:28391
See related
Ensembl:ENSG00000157303 MIM:616429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 12.2), lymph node (RPKM 7.6) and 12 other tissues See more
Orthologs
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Genomic context

See SUSD3 in Genome Data Viewer
Location:
9q22.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (93058701..93085138)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95820983..95847415)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase pseudogene 2 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene uncharacterized LOC101927954 Neighboring gene Sharpr-MPRA regulatory region 12079 Neighboring gene uncharacterized LOC101927993 Neighboring gene caspase recruitment domain family member 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26847

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sushi domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287005.2NP_001273934.1  sushi domain-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_001273934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an additional exon in the 5' region, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AY358190, DT220823
    Consensus CDS
    CCDS69620.1
    UniProtKB/Swiss-Prot
    Q96L08
    Related
    ENSP00000364618.1, ENST00000375469.5
    Conserved Domains (1) summary
    cd00033
    Location:1979
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  2. NM_001287006.2NP_001273935.1  sushi domain-containing protein 3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AY358190, DR007158, DT220823
    Consensus CDS
    CCDS75857.1
    UniProtKB/Swiss-Prot
    Q96L08
    UniProtKB/TrEMBL
    A0A087WVN2
    Related
    ENSP00000479555.1, ENST00000617293.4
    Conserved Domains (1) summary
    cd00033
    Location:3292
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  3. NM_001287007.2NP_001273936.1  sushi domain-containing protein 3 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in both the 5' and 3' coding regions, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    BM458621, CB047753, DT220823
    Related
    ENSP00000474695.1, ENST00000471462.2
  4. NM_001287008.2NP_001273937.1  sushi domain-containing protein 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a.
    Source sequence(s)
    AI452970, AY358190, DT220823
    UniProtKB/Swiss-Prot
    Q96L08
  5. NM_145006.4NP_659443.1  sushi domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_659443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AY358190, BC014601, DT220823
    Consensus CDS
    CCDS6701.1
    UniProtKB/Swiss-Prot
    Q96L08
    Related
    ENSP00000364621.3, ENST00000375472.8
    Conserved Domains (1) summary
    cd00033
    Location:3292
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    93058701..93085138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014450.1XP_016869939.1  sushi domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q96L08
    Conserved Domains (1) summary
    cd00033
    Location:1979
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  2. XM_017014448.1XP_016869937.1  sushi domain-containing protein 3 isoform X1

  3. XM_017014449.1XP_016869938.1  sushi domain-containing protein 3 isoform X1

  4. XM_011518361.2XP_011516663.1  sushi domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011516663.1

    UniProtKB/Swiss-Prot
    Q96L08
    Conserved Domains (1) summary
    cd00033
    Location:1979
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  5. XM_011518358.1XP_011516660.1  sushi domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011516660.1

    UniProtKB/Swiss-Prot
    Q96L08
    Conserved Domains (1) summary
    cd00033
    Location:1979
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  6. XM_011518359.1XP_011516661.1  sushi domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011516661.1

    UniProtKB/Swiss-Prot
    Q96L08
    Conserved Domains (1) summary
    cd00033
    Location:1979
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  7. XM_011518362.1XP_011516664.1  sushi domain-containing protein 3 isoform X4

    Conserved Domains (1) summary
    cd00033
    Location:235
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  8. XM_017014451.2XP_016869940.1  sushi domain-containing protein 3 isoform X3

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