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TMEM268 transmembrane protein 268 [ Homo sapiens (human) ]

Gene ID: 203197, updated on 5-Aug-2022

Summary

Official Symbol
TMEM268provided by HGNC
Official Full Name
transmembrane protein 268provided by HGNC
Primary source
HGNC:HGNC:24513
See related
Ensembl:ENSG00000157693 AllianceGenome:HGNC:24513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf91
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.4), spleen (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM268 in Genome Data Viewer
Location:
9q32
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (114603904..114646422)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (126803709..126838835)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117373571..117408702)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376229 Neighboring gene small nucleolar RNA U13 Neighboring gene ATPase H+ transporting V1 subunit G1 Neighboring gene uncharacterized LOC107987121 Neighboring gene testis expressed 53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38045, MGC129868, MGC129869, DKFZp547P234

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 268
Names
transmembrane protein C9orf91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330760.2NP_001317689.1  transmembrane protein 268 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL160275, AL557166, AL834412, AW963631, BC010029, CB121579, DB199443, HY066490
    Consensus CDS
    CCDS83405.1
    UniProtKB/Swiss-Prot
    Q5VZI3
    Related
    ENSP00000363161.4, ENST00000374049.4
  2. NM_153045.4NP_694590.2  transmembrane protein 268 isoform 1

    See identical proteins and their annotated locations for NP_694590.2

    Status: VALIDATED

    Source sequence(s)
    AK095364, AL160275, BC010029, BC107133, DB199443
    Consensus CDS
    CCDS6808.1
    UniProtKB/Swiss-Prot
    Q5VZI3, Q8ND43
    Related
    ENSP00000288502.4, ENST00000288502.9
    Conserved Domains (1) summary
    pfam14800
    Location:38328
    DUF4481; Domain of unknown function (DUF4481)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    114603904..114646422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518351.3XP_011516653.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_011516653.1

    Conserved Domains (1) summary
    pfam14800
    Location:104395
    DUF4481; Domain of unknown function (DUF4481)
  2. XM_047422925.1XP_047278881.1  transmembrane protein 268 isoform X6

    UniProtKB/Swiss-Prot
    Q8ND43
  3. XM_011518350.2XP_011516652.1  transmembrane protein 268 isoform X1

    See identical proteins and their annotated locations for XP_011516652.1

    Conserved Domains (1) summary
    pfam14800
    Location:104395
    DUF4481; Domain of unknown function (DUF4481)
  4. XM_011518353.2XP_011516655.1  transmembrane protein 268 isoform X3

    Conserved Domains (1) summary
    pfam14800
    Location:104358
    DUF4481; Domain of unknown function (DUF4481)
  5. XM_011518352.2XP_011516654.1  transmembrane protein 268 isoform X2

    Conserved Domains (1) summary
    pfam14800
    Location:104394
    DUF4481; Domain of unknown function (DUF4481)
  6. XM_047422923.1XP_047278879.1  transmembrane protein 268 isoform X4

  7. XM_047422927.1XP_047278883.1  transmembrane protein 268 isoform X9

  8. XM_047422928.1XP_047278884.1  transmembrane protein 268 isoform X10

  9. XM_024447441.1XP_024303209.1  transmembrane protein 268 isoform X6

    UniProtKB/Swiss-Prot
    Q8ND43
    Conserved Domains (1) summary
    pfam14800
    Location:38328
    DUF4481; Domain of unknown function (DUF4481)
  10. XM_047422924.1XP_047278880.1  transmembrane protein 268 isoform X5

  11. XM_011518354.2XP_011516656.1  transmembrane protein 268 isoform X7

    Conserved Domains (1) summary
    pfam14800
    Location:17308
    DUF4481; Domain of unknown function (DUF4481)
  12. XM_047422929.1XP_047278885.1  transmembrane protein 268 isoform X11

  13. XM_011518355.2XP_011516657.1  transmembrane protein 268 isoform X8

    See identical proteins and their annotated locations for XP_011516657.1

    UniProtKB/Swiss-Prot
    Q5VZI3
    Conserved Domains (1) summary
    pfam14800
    Location:17307
    DUF4481; Domain of unknown function (DUF4481)
  14. XM_017014430.2XP_016869919.1  transmembrane protein 268 isoform X12

RNA

  1. XR_001746225.2 RNA Sequence

  2. XR_007061260.1 RNA Sequence

  3. XR_001746226.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    126803709..126838835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)