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TMEM184A transmembrane protein 184A [ Homo sapiens (human) ]

Gene ID: 202915, updated on 6-Nov-2022

Summary

Official Symbol
TMEM184Aprovided by HGNC
Official Full Name
transmembrane protein 184Aprovided by HGNC
Primary source
HGNC:HGNC:28797
See related
Ensembl:ENSG00000164855 AllianceGenome:HGNC:28797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDMG1
Summary
Predicted to enable heparin binding activity. Predicted to act upstream of or within germ-line sex determination; regulation of protein localization; and regulation of secretion. Predicted to be located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in early endosome membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine (RPKM 9.8), duodenum (RPKM 8.8) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM184A in Genome Data Viewer
Location:
7p22.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1542235..1556205, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1654363..1668333, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1581871..1595841, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901572 Neighboring gene uncharacterized LOC100128653 Neighboring gene Sharpr-MPRA regulatory region 13805 Neighboring gene MAF bZIP transcription factor K Neighboring gene Sharpr-MPRA regulatory region 1064 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:1606554-1607122 and GRCh37_chr7:1607123-1607691 Neighboring gene PSMG3 antisense RNA 1 (head to head) Neighboring gene proteasome assembly chaperone 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9712, FLJ24011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 184A
Names
sexually dimorphic, expressed in male gonads 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097620.2NP_001091089.1  transmembrane protein 184A

    See identical proteins and their annotated locations for NP_001091089.1

    Status: VALIDATED

    Source sequence(s)
    AC093734, AK172850, BM981655
    Consensus CDS
    CCDS43537.1
    UniProtKB/Swiss-Prot
    Q6ZMB5, Q8TBQ6
    Related
    ENSP00000297477.4, ENST00000297477.10
    Conserved Domains (1) summary
    pfam03619
    Location:55325
    Solute_trans_a; Organic solute transporter Ostalpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    1542235..1556205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    1654363..1668333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152689.2: Suppressed sequence

    Description
    NM_152689.2: This RefSeq was permanently suppressed because it contains the wrong CDS.