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Scg3 secretogranin III [ Mus musculus (house mouse) ]

Gene ID: 20255, updated on 5-Mar-2024

Summary

Official Symbol
Scg3provided by MGI
Official Full Name
secretogranin IIIprovided by MGI
Primary source
MGI:MGI:103032
See related
Ensembl:ENSMUSG00000032181 AllianceGenome:MGI:103032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chgd; SgIII; 1B1075
Summary
Acts upstream of or within protein localization to secretory granule. Located in secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human SCG3 (secretogranin III). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 14.7), cortex adult (RPKM 13.8) and 7 other tissues See more
Orthologs
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Genomic context

See Scg3 in Genome Data Viewer
Location:
9 D; 9 42.32 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75550648..75591733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75643366..75685959, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:75429888-75430189 Neighboring gene tropomodulin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75478519-75478819 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_24672 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_24674 Neighboring gene STARR-seq mESC enhancer starr_24675 Neighboring gene predicted gene, 39373

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein localization to secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein localization to secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in secretory granule membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164790.1NP_001158262.1  secretogranin-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001158262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to variant 1.
    Source sequence(s)
    AK139140, AK164089, BU058741
    Consensus CDS
    CCDS90627.1
    UniProtKB/Swiss-Prot
    P47867
    Related
    ENSMUSP00000149561.2, ENSMUST00000213324.2
    Conserved Domains (1) summary
    pfam15467
    Location:20466
    SGIII; Secretogranin-3
  2. NM_009130.3NP_033156.1  secretogranin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK139140, BU058741
    Consensus CDS
    CCDS23347.1
    UniProtKB/Swiss-Prot
    P47867, Q3UTT1, Q3UZT8, Q8R1D7
    Related
    ENSMUSP00000034699.7, ENSMUST00000034699.8
    Conserved Domains (1) summary
    pfam15467
    Location:20471
    SGIII; Secretogranin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75550648..75591733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313220.3XP_017168709.1  secretogranin-3 isoform X2

    Conserved Domains (1) summary
    pfam15467
    Location:29433
    SGIII; Secretogranin-3
  2. XM_006510881.5XP_006510944.1  secretogranin-3 isoform X1

    Conserved Domains (1) summary
    pfam15467
    Location:29438
    SGIII; Secretogranin-3