U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sat1 spermidine/spermine N1-acetyl transferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20229, updated on 8-Feb-2024

Summary

Official Symbol
Sat1provided by MGI
Official Full Name
spermidine/spermine N1-acetyl transferase 1provided by MGI
Primary source
MGI:MGI:98233
See related
Ensembl:ENSMUSG00000025283 AllianceGenome:MGI:98233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sat; SSAT
Summary
Predicted to enable diamine N-acetyltransferase activity; identical protein binding activity; and spermidine binding activity. Acts upstream of or within regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 89.1), placenta adult (RPKM 43.0) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Sat1 in Genome Data Viewer
Location:
X F3; X 72.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (153996128..153999345, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (155213126..155216449, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 1 Neighboring gene 60S acidic ribosomal protein P0-like Neighboring gene STARR-seq mESC enhancer starr_48134 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48136 Neighboring gene acyl-CoA thioesterase 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
 
enables diamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables diamine N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables spermidine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables spermidine binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in polyamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in polyamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in polyamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in spermidine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spermidine acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermine catabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
diamine acetyltransferase 1
Names
SSAT-1
polyamine N-acetyltransferase 1
putrescine acetyltransferase
spermidine/spermine N(1)-acetyltransferase 1
NP_001412931.1
NP_033147.1
XP_036017762.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426002.1NP_001412931.1  diamine acetyltransferase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (3).
    Source sequence(s)
    BX119978, BX119986
    UniProtKB/TrEMBL
    A2BES2
  2. NM_009121.5NP_033147.1  diamine acetyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_033147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BX119978, BX119986
    Consensus CDS
    CCDS30495.1
    UniProtKB/Swiss-Prot
    P48026, Q3U444
    Related
    ENSMUSP00000026318.9, ENSMUST00000026318.15
    Conserved Domains (1) summary
    pfam00583
    Location:48144
    Acetyltransf_1; Acetyltransferase (GNAT) family

RNA

  1. NR_189657.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX119978, BX119986
  2. NR_189658.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX119978, BX119986

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    153996128..153999345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161869.1XP_036017762.1  diamine acetyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    Q3V2Q2
    Related
    ENSMUST00000150046.2
    Conserved Domains (1) summary
    pfam00583
    Location:469
    Acetyltransf_1; Acetyltransferase (GNAT) family