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Acsm3 acyl-CoA synthetase medium-chain family member 3 [ Mus musculus (house mouse) ]

Gene ID: 20216, updated on 2-Nov-2024

Summary

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Official Symbol
Acsm3provided by MGI
Official Full Name
acyl-CoA synthetase medium-chain family member 3provided by MGI
Primary source
MGI:MGI:99538
See related
Ensembl:ENSMUSG00000030935 AllianceGenome:MGI:99538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sa; Sah
Summary
Enables medium-chain fatty acid-CoA ligase activity and propionate CoA-transferase activity. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrial matrix. Is expressed in alimentary system; integumental system; and lower urinary tract. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human ACSM3 (acyl-CoA synthetase medium chain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E18 (RPKM 13.3), liver adult (RPKM 7.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Acsm3 in Genome Data Viewer
Location:
7 F2; 7 64.17 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119360106..119384119)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119760883..119784896)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 catalytic subunit gamma B Neighboring gene UPF0124 protein C13orf31 homolog Neighboring gene predicted gene, 57786 Neighboring gene exoribonuclease 2 Neighboring gene RNA exonuclease 5 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4α-p38 MAPK axis. Xiao X, et al. EMBO J, 2024 Feb. PMID 38191811, Free PMC Article
  2. Analysis of the role of the SA gene in blood pressure regulation by gene targeting. Walsh V, et al. Hypertension, 2003 Jun. PMID 12707288
  3. Sex steroid regulation and identification of different transcription units of the SA gene in mouse kidney. Aresté C, et al. J Endocrinol, 2004 Oct. PMID 15525578
  4. High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes. Choi MS, et al. Br J Nutr, 2015 Mar 28. PMID 25744306
  5. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. Fujino T, et al. J Biol Chem, 2001 Sep 21. PMID 11470804

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4alpha-p38 MAPK axis.
    Title: Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4α-p38 MAPK axis.
  2. Data suggest that expression of Acsm3 in adipose tissue can be regulated by dietary factors; here, expression of Acsm3 in white adipose tissue is down-regulated in obesity caused by high-fat diet.
    Title: High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes.
  3. Analysis of the role of the SA gene in blood pressure regulation.
    Title: Analysis of the role of the SA gene in blood pressure regulation by gene targeting.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-methylbutanoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables medium-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables medium-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables propionate CoA-transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables propionate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acyl-coenzyme A synthetase ACSM3, mitochondrial
Names
SA hypertension-associated homolog
butyrate--CoA ligase 3
butyryl-coenzyme A synthetase 3
middle-chain acyl-CoA synthetase 3
propionate--CoA ligase
protein SA homolog
NP_058566.3
NP_997606.2
NP_997607.2
XP_006507538.1
XP_017177549.1
XP_017177550.1
XP_017177551.1
XP_017177552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016870.4 → NP_058566.3  acyl-coenzyme A synthetase ACSM3, mitochondrial

    See identical proteins and their annotated locations for NP_058566.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcripts. The three transcript variants all encode the same protein.
    Source sequence(s)
    AC164158
    Consensus CDS
    CCDS21786.1
    UniProtKB/Swiss-Prot
    Q3UNX5, Q8BRY2, Q91WI1, Q9Z2F3, Q9Z2X0
    Related
    ENSMUSP00000102138.2, ENSMUST00000106528.8
    Conserved Domains (1) summary
    cd05928
    Location:48 → 577
    MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

  2. NM_212441.3 → NP_997606.2  acyl-coenzyme A synthetase ACSM3, mitochondrial

    See identical proteins and their annotated locations for NP_997606.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' UTR, compared to variant 1. The three transcript variants all encode the same protein.
    Source sequence(s)
    AC164158
    Consensus CDS
    CCDS21786.1
    UniProtKB/Swiss-Prot
    Q3UNX5, Q8BRY2, Q91WI1, Q9Z2F3, Q9Z2X0
    Related
    ENSMUSP00000068803.4, ENSMUST00000063770.10
    Conserved Domains (1) summary
    cd05928
    Location:48 → 577
    MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

  3. NM_212442.3 → NP_997607.2  acyl-coenzyme A synthetase ACSM3, mitochondrial

    See identical proteins and their annotated locations for NP_997607.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame segment in the 5' UTR, compared to variant 1. The three transcript variants all encode the same protein.
    Source sequence(s)
    AC164158
    Consensus CDS
    CCDS21786.1
    UniProtKB/Swiss-Prot
    Q3UNX5, Q8BRY2, Q91WI1, Q9Z2F3, Q9Z2X0
    Related
    ENSMUSP00000102137.2, ENSMUST00000106527.8
    Conserved Domains (1) summary
    cd05928
    Location:48 → 577
    MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119360106..119384119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322060.2 → XP_017177549.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl17068
    Location:48 → 554
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_017322063.2 → XP_017177552.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd05928
    Location:48 → 578
    MACS_euk; Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM)

  3. XM_006507475.4 → XP_006507538.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006507538.1

    Conserved Domains (1) summary
    cl17068
    Location:48 → 553
    AFD_class_I; Adenylate forming domain, Class I superfamily

  4. XM_017322061.3 → XP_017177550.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl17068
    Location:48 → 554
    AFD_class_I; Adenylate forming domain, Class I superfamily

  5. XM_017322062.2 → XP_017177551.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl17068
    Location:48 → 554
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UNX5.2 GenPept UniProtKB/Swiss-Prot:Q3UNX5

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