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DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 [ Homo sapiens (human) ]

Gene ID: 202052, updated on 22-Sep-2022

Summary

Official Symbol
DNAJC18provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C18provided by HGNC
Primary source
HGNC:HGNC:28429
See related
Ensembl:ENSG00000170464 AllianceGenome:HGNC:28429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable Hsp70 protein binding activity. Predicted to be involved in cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 11.6), testis (RPKM 9.5) and 21 other tissues See more
Orthologs
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Genomic context

See DNAJC18 in Genome Data Viewer
Location:
5q31.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139410203..139439525, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139936006..139965339, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138745892..138775214, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 996 Neighboring gene spermatogenesis associated 24 Neighboring gene proline rich basic protein 1 Neighboring gene uncharacterized LOC124901082 Neighboring gene RNA, U5B small nuclear 4, pseudogene Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ECSCR

Homology

Clone Names

  • FLJ56777, MGC29463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily C member 18
Names
DnaJ (Hsp40) homolog, subfamily C, member 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152686.4NP_689899.1  dnaJ homolog subfamily C member 18

    See identical proteins and their annotated locations for NP_689899.1

    Status: VALIDATED

    Source sequence(s)
    AC142391, BC030162, BU735127, DA497858
    Consensus CDS
    CCDS4214.1
    UniProtKB/Swiss-Prot
    Q9H819
    Related
    ENSP00000302843.5, ENST00000302060.10
    Conserved Domains (2) summary
    pfam00226
    Location:82143
    DnaJ; DnaJ domain
    pfam09320
    Location:250350
    DUF1977; Domain of unknown function (DUF1977)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    139410203..139439525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021159996.1 Reference GRCh38.p14 PATCHES

    Range
    732..30054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    139936006..139965339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)