S100a6 S100 calcium binding protein A6 (calcyclin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a6provided by MGI
Official Full Name: S100 calcium binding protein A6 (calcyclin)provided by MGI
Primary source: MGI:MGI:1339467
See related: Ensembl:ENSMUSG00000001025 AllianceGenome:MGI:1339467
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2A9; PRA; 5B10; Cacy; CALCYCLIN
Summary: Enables calcium ion binding activity and zinc ion binding activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and trophectoderm. Orthologous to human S100A6 (S100 calcium binding protein A6). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in bladder adult (RPKM 1598.0), colon adult (RPKM 575.5) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 3 F1; 3 39.35 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90520491..90531797)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90612894..90614414)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100a6 knockdown promotes the differentiation of dental epithelial cells toward the epidermal lineage instead of the odontogenic lineage.
Title: S100a6 knockdown promotes the differentiation of dental epithelial cells toward the epidermal lineage instead of the odontogenic lineage.
The S100 calcium-binding protein A6 plays a crucial role in hepatic steatosis by mediating lipophagy.
Title: The S100 calcium-binding protein A6 plays a crucial role in hepatic steatosis by mediating lipophagy.
S100A6 Activates Kupffer Cells via the p-P38 and p-JNK Pathways to Induce Inflammation, Mononuclear/macrophage Infiltration Sterile Liver Injury in Mice.
Title: S100A6 Activates Kupffer Cells via the p-P38 and p-JNK Pathways to Induce Inflammation, Mononuclear/macrophage Infiltration Sterile Liver Injury in Mice.
Liver-Derived S100A6 Propels beta-Cell Dysfunction in NAFLD.
Title: Liver-Derived S100A6 Propels β-Cell Dysfunction in NAFLD.
Binding of S100A6 to actin and the actin-tropomyosin complex.
Title: Binding of S100A6 to actin and the actin-tropomyosin complex.
miR-202-3p overexpression attenuates endometriosis-like lesions by modulating YAP-dependent transcription of S100A6 in murine models.
Title: miR-202-3p overexpression attenuates endometriosis-like lesions by modulating YAP-dependent transcription of S100A6 in murine models.
our data provide the first evidence that S100A6 is a specific marker of neural stem cells and astrocyte precursors
Title: S100A6 (calcyclin) is a novel marker of neural stem cells and astrocyte precursors in the subgranular zone of the adult mouse hippocampus.
new insight into the interaction between S100 proteins and CacyBP/SIP
Title: S100A6 protein negatively regulates CacyBP/SIP-mediated inhibition of gastric cancer cell proliferation and tumorigenesis.
the S100A6 protein is involved in multiple aspects of fibroblast physiology and that its presence ensures normal fibroblast proliferation and function
Title: S100A6 (calcyclin) deficiency induces senescence-like changes in cell cycle, morphology and functional characteristics of mouse NIH 3T3 fibroblasts.
S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients
Title: Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S100 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables S100 protein binding	IEA Inferred from Electronic Annotation more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables monoatomic ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tropomyosin binding	IEA Inferred from Electronic Annotation more info
enables tropomyosin binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular matrix	HDA more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A6

Names: S100 calcium-binding protein A6; calcium binding protein A6 (calcyclin); prolactin receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417970.1 → NP_001404899.1 protein S100-A6 isoform 1

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P14069

UniProtKB/TrEMBL

Q545I9

Related

ENSMUSP00000356046.1, ENSMUST00000577683.1
NM_001417971.1 → NP_001404900.1 protein S100-A6 isoform 1

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P14069

UniProtKB/TrEMBL

Q545I9

Related

ENSMUSP00000333802.1, ENSMUST00000555439.1
NM_001417972.1 → NP_001404901.1 protein S100-A6 isoform 1

Status: VALIDATED

Source sequence(s)

AC160552

UniProtKB/Swiss-Prot

P14069

UniProtKB/TrEMBL

Q545I9

Related

ENSMUSP00000143111.2, ENSMUST00000198128.3
NM_001417973.1 → NP_001404902.1 protein S100-A6 isoform 2

Status: VALIDATED

Source sequence(s)

AC160552

Related

ENSMUSP00000361327.1, ENSMUST00000582962.1
NM_001417974.1 → NP_001404903.1 protein S100-A6 isoform 3

Status: VALIDATED

Source sequence(s)

AC160552

Related

ENSMUSP00000361326.1, ENSMUST00000582961.1
NM_001417975.1 → NP_001404904.1 protein S100-A6 isoform 4

Status: VALIDATED

Source sequence(s)

AC160552
NM_001417976.1 → NP_001404905.1 protein S100-A6 isoform 5

Status: VALIDATED

Source sequence(s)

AC160552

Related

ENSMUSP00000361328.1, ENSMUST00000582963.1
NM_001417977.1 → NP_001404906.1 protein S100-A6 isoform 6

Status: VALIDATED

Source sequence(s)

AC160552

Related

ENSMUSP00000361329.1, ENSMUST00000582964.1
NM_011313.3 → NP_035443.1 protein S100-A6 isoform 1

See identical proteins and their annotated locations for NP_035443.1

Status: VALIDATED

Source sequence(s)

AC160552

Consensus CDS

CCDS38506.1

UniProtKB/Swiss-Prot

P14069

UniProtKB/TrEMBL

Q545I9

Related

ENSMUSP00000001051.5, ENSMUST00000001051.10

Conserved Domains (1) summary

cd05029
Location:1 → 88

S-100A6; S-100A6 domain found in proteins similar to S100A6. S100A6 is a member of the S100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A6 group belongs, contains only S-100 EF-hand domains, ...