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Rxrg retinoid X receptor gamma [ Mus musculus (house mouse) ]

Gene ID: 20183, updated on 8-Feb-2024

Summary

Official Symbol
Rxrgprovided by MGI
Official Full Name
retinoid X receptor gammaprovided by MGI
Primary source
MGI:MGI:98216
See related
Ensembl:ENSMUSG00000015843 AllianceGenome:MGI:98216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nr2b3
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and nuclear receptor activity. Acts upstream of or within positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus and retinoic acid receptor signaling pathway. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculature; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human RXRG (retinoid X receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 24.1), CNS E18 (RPKM 10.1) and 10 other tissues See more
Orthologs
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Genomic context

See Rxrg in Genome Data Viewer
Location:
1 H2.3; 1 74.99 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167425902..167467191)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167598362..167639623)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4379 Neighboring gene microsomal glutathione S-transferase 3 Neighboring gene predicted gene, 34207 Neighboring gene STARR-seq mESC enhancer starr_02951 Neighboring gene leucine rich repeat containing 52 Neighboring gene STARR-seq mESC enhancer starr_02952 Neighboring gene LIM homeobox transcription factor 1 alpha Neighboring gene STARR-seq mESC enhancer starr_02953 Neighboring gene STARR-seq mESC enhancer starr_02954 Neighboring gene STARR-seq mESC enhancer starr_02955 Neighboring gene STARR-seq mESC enhancer starr_02957 Neighboring gene STARR-seq mESC enhancer starr_02958 Neighboring gene pre B cell leukemia homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_02965 Neighboring gene predicted gene, 51671

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables retinoic acid-responsive element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinoic acid receptor RXR-gamma
Names
nuclear receptor subfamily 2 group B member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159731.2NP_001153203.1  retinoic acid receptor RXR-gamma isoform 2

    See identical proteins and their annotated locations for NP_001153203.1

    Status: VALIDATED

    Source sequence(s)
    AC093318, AC093452
    Consensus CDS
    CCDS48435.1
    UniProtKB/TrEMBL
    E9Q9V9
    Related
    ENSMUSP00000107011.2, ENSMUST00000111380.2
    Conserved Domains (2) summary
    cd06943
    Location:110318
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:1490
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
  2. NM_001420495.1NP_001407424.1  retinoic acid receptor RXR-gamma isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093318, AC093452
  3. NM_001420496.1NP_001407425.1  retinoic acid receptor RXR-gamma isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093318, AC093452
    UniProtKB/TrEMBL
    E9Q9V9
  4. NM_009107.4NP_033133.1  retinoic acid receptor RXR-gamma isoform 1

    See identical proteins and their annotated locations for NP_033133.1

    Status: VALIDATED

    Source sequence(s)
    AC093318, AC093452
    Consensus CDS
    CCDS15459.1
    UniProtKB/Swiss-Prot
    P28705
    Related
    ENSMUSP00000015987.4, ENSMUST00000015987.10
    Conserved Domains (3) summary
    cd06943
    Location:233441
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:137213
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:25133
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    167425902..167467191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)