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EMP3 epithelial membrane protein 3 [ Homo sapiens (human) ]

Gene ID: 2014, updated on 20-Dec-2019

Summary

Official Symbol
EMP3provided by HGNC
Official Full Name
epithelial membrane protein 3provided by HGNC
Primary source
HGNC:HGNC:3335
See related
Ensembl:ENSG00000142227 MIM:602335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YMP
Summary
The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 63.7), appendix (RPKM 40.0) and 24 other tissues See more
Orthologs

Genomic context

See EMP3 in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48325504..48330554)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48828629..48833810)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF114 antisense RNA 1 Neighboring gene zinc finger protein 114 Neighboring gene coiled-coil domain containing 114 Neighboring gene Sharpr-MPRA regulatory region 73 Neighboring gene transmembrane protein 143 Neighboring gene synaptogyrin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
bleb assembly IDA
Inferred from Direct Assay
more info
PubMed 
cell death IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
epithelial membrane protein 3
Names
EMP-3
HNMP-1
hematopoietic neural membrane protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313905.1NP_001300834.1  epithelial membrane protein 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC008392
    Consensus CDS
    CCDS12715.1
    UniProtKB/Swiss-Prot
    P54852
    UniProtKB/TrEMBL
    A0A024QZF8
    Conserved Domains (1) summary
    pfam00822
    Location:20156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  2. NM_001425.3NP_001416.1  epithelial membrane protein 3

    See identical proteins and their annotated locations for NP_001416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL541088, BC009718
    Consensus CDS
    CCDS12715.1
    UniProtKB/Swiss-Prot
    P54852
    UniProtKB/TrEMBL
    A0A024QZF8
    Related
    ENSP00000270221.5, ENST00000270221.11
    Conserved Domains (1) summary
    pfam00822
    Location:20156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48325504..48330554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526605.3XP_011524907.1  epithelial membrane protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011524907.1

    UniProtKB/Swiss-Prot
    P54852
    UniProtKB/TrEMBL
    A0A024QZF8
    Related
    ENSP00000469194.1, ENST00000597279.5
    Conserved Domains (1) summary
    pfam00822
    Location:20156
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
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