Format

Send to:

Choose Destination

RDM1 RAD52 motif containing 1 [ Homo sapiens (human) ]

Gene ID: 201299, updated on 18-Aug-2020

Summary

Official Symbol
RDM1provided by HGNC
Official Full Name
RAD52 motif containing 1provided by HGNC
Primary source
HGNC:HGNC:19950
See related
Ensembl:ENSG00000278023 MIM:612896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAD52B
Summary
This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 2.2), lymph node (RPKM 0.3) and 5 other tissues See more
Orthologs

Genomic context

See RDM1 in Genome Data Viewer
Location:
17q12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (35918080..35931821, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34245084..34257780, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37, member A3 pseudogene Neighboring gene leucine rich repeat containing 37 member A9, pseudogene Neighboring gene lysozyme like 6 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene C-C motif chemokine ligand 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33977

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Cajal body IEA
Inferred from Electronic Annotation
more info
 
PML body IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
RAD52 motif-containing protein 1
Names
RAD52 homolog B
RAD52 motif 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034836.2NP_001030008.1  RAD52 motif-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001030008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant(2) differs in the 3' coding region and UTR, compared to variant 1. This results in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC004675, AC244100, BM559857
    Consensus CDS
    CCDS42299.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000482288.1, ENST00000613308.4
    Conserved Domains (1) summary
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  2. NM_001163120.2NP_001156592.1  RAD52 motif-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001156592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3, also known as zeta) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BU599050, BX376188, EF488478
    Consensus CDS
    CCDS54110.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000483387.1, ENST00000612980.4
    Conserved Domains (1) summary
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  3. NM_001163121.2NP_001156593.1  RAD52 motif-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001156593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4, also known as gamma) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BU599050, BX376188, EF488475
    Consensus CDS
    CCDS54111.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000478915.1, ENST00000616596.4
    Conserved Domains (1) summary
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  4. NM_001163122.1NP_001156594.1  RAD52 motif-containing protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001156594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5, also known as DeltaN-gamma) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AW138754, BX376188, EF488481
    Consensus CDS
    CCDS59281.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000483933.1, ENST00000619828.4
    Conserved Domains (1) summary
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  5. NM_001163124.1NP_001156596.1  RAD52 motif-containing protein 1 isoform 6

    See identical proteins and their annotated locations for NP_001156596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (6, also known as DeltaN-zeta) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AW138754, BX376188, EF488473
    Consensus CDS
    CCDS59280.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000479622.1, ENST00000617591.4
    Conserved Domains (1) summary
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  6. NM_001163125.1NP_001156597.1  RAD52 motif-containing protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001156597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' and 3' UTRs and coding sequence and lacks an alternate internal coding exon compared to variant 1. The resulting isoform (7) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AA761980, AC244100, AW138754
    Consensus CDS
    CCDS54108.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000480131.1, ENST00000615378.1
    Conserved Domains (1) summary
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  7. NM_001163130.1NP_001156602.1  RAD52 motif-containing protein 1 isoform 8

    See identical proteins and their annotated locations for NP_001156602.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (8, also known as DeltaN-alpha) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AW138754, BX376188, EF488479
    Consensus CDS
    CCDS54109.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000479310.1, ENST00000619262.4
    Conserved Domains (1) summary
    cd12364
    Location:1072
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  8. NM_001330194.2NP_001317123.1  RAD52 motif-containing protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC244100
    Consensus CDS
    CCDS82109.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000482981.1, ENST00000619193.4
    Conserved Domains (1) summary
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins
  9. NM_145654.4NP_663629.1  RAD52 motif-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_663629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1, also known as isoform alpha).
    Source sequence(s)
    AB080728, BU599050, BX376188
    Consensus CDS
    CCDS11301.1
    UniProtKB/Swiss-Prot
    Q8NG50
    Related
    ENSP00000483549.1, ENST00000620284.5
    Conserved Domains (1) summary
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins

RNA

  1. NR_027996.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as delta) lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    BU599050, BX376188, EF488476
  2. NR_027997.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as beta) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    BU599050, BX376188, EF488474
  3. NR_027998.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as epsilon) lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    BU599050, BX376188, EF488477
  4. NR_027999.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as DeltaN-epsilon) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The lack of one of the exons causes a frameshift and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    AW138754, BX376188, EF488482
  5. NR_028000.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as DeltaN-beta) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD), so it is not thought to encode a protein.
    Source sequence(s)
    AW138754, BX376188, EF488480

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    35918080..35931821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524509.2XP_011522811.1  RAD52 motif-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011522811.1

    Conserved Domains (1) summary
    cd12364
    Location:1595
    RRM_RDM1; RNA recognition motif of RAD52 motif-containing protein 1 (RDM1) and similar proteins

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    152612..165305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center