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SLC39A11 solute carrier family 39 member 11 [ Homo sapiens (human) ]

Gene ID: 201266, updated on 15-Jun-2019

Summary

Official Symbol
SLC39A11provided by HGNC
Official Full Name
solute carrier family 39 member 11provided by HGNC
Primary source
HGNC:HGNC:14463
See related
Ensembl:ENSG00000133195 MIM:616508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP11; ZIP-11; C17orf26
Expression
Ubiquitous expression in thyroid (RPKM 5.6), stomach (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See SLC39A11 in Genome Data Viewer
Location:
17q24.3-q25.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (72645946..73092714, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (70642085..71088853, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 511 Neighboring gene uncharacterized LOC107985005 Neighboring gene uncharacterized LOC105371887 Neighboring gene ribosomal protein L32 pseudogene 33 Neighboring gene RN7SK pseudogene 180 Neighboring gene autophagy related 12 pseudogene 1 Neighboring gene RNA polymerase III subunit K pseudogene 2 Neighboring gene somatostatin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
NHGRI GWA Catalog
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide association study of liver enzymes in korean children.
NHGRI GWA Catalog
Genome-wide association study of serum selenium concentrations.
NHGRI GWA Catalog
Genome-wide association study of smoking behaviours among Bangladeshi adults.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
NHGRI GWA Catalog

Pathways from BioSystems

  • NRF2 pathway, organism-specific biosystem (from WikiPathways)
    NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
  • Zinc homeostasis, organism-specific biosystem (from WikiPathways)
    Zinc homeostasis, organism-specific biosystemZinc is a transition metal and catalytic cofactor involved in many biological processes such as proliferation, development and differentiation, regulation of DNA synthesis, genomic stability, cell ac...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc transporter ZIP11
Names
Zrt- and Irt-like protein 11
solute carrier family 39 (metal ion transporter), member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159770.2NP_001153242.1  zinc transporter ZIP11 isoform 1

    See identical proteins and their annotated locations for NP_001153242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 3. The encoded isoform (1) is longer, compared to isoform 2. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC025198, AC080037, AK095227, BU686998, DA380043
    Consensus CDS
    CCDS54160.1
    UniProtKB/Swiss-Prot
    Q8N1S5
    Related
    ENSP00000445829.2, ENST00000542342.6
    Conserved Domains (1) summary
    COG0428
    Location:6342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  2. NM_001352691.2NP_001339620.1  zinc transporter ZIP11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript but encodes the shorter isoform (2). Variants 2, 3, and 5 encode the same isoform (2).
    Source sequence(s)
    AC011120, AC025198, AC080037
    Consensus CDS
    CCDS11690.1
    Conserved Domains (1) summary
    COG0428
    Location:6335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  3. NM_001352692.2NP_001339621.1  zinc transporter ZIP11 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 3. The encoded isoform (1) is longer, compared to isoform 2. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC011120, AC025198, AC080037
    Consensus CDS
    CCDS54160.1
    Conserved Domains (1) summary
    COG0428
    Location:6342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  4. NM_001352693.2NP_001339622.1  zinc transporter ZIP11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 2, 3, and 5 encode the same isoform (2).
    Source sequence(s)
    AC011120, AC025198, AC080037
    Consensus CDS
    CCDS11690.1
    Conserved Domains (1) summary
    COG0428
    Location:6335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  5. NM_139177.4NP_631916.2  zinc transporter ZIP11 isoform 2

    See identical proteins and their annotated locations for NP_631916.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 2, 3, and 5 encode the same isoform (2).
    Source sequence(s)
    AC025198, BC035631
    Consensus CDS
    CCDS11690.1
    UniProtKB/Swiss-Prot
    Q8N1S5
    Related
    ENSP00000255559.3, ENST00000255559.7
    Conserved Domains (1) summary
    COG0428
    Location:6335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    72645949..73092714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024335.1XP_016879824.1  zinc transporter ZIP11 isoform X7

  2. XM_006721757.2XP_006721820.1  zinc transporter ZIP11 isoform X5

    Conserved Domains (1) summary
    COG0428
    Location:6285
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  3. XM_017024330.1XP_016879819.1  zinc transporter ZIP11 isoform X2

    UniProtKB/Swiss-Prot
    Q8N1S5
    Conserved Domains (1) summary
    COG0428
    Location:6335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  4. XM_006721755.2XP_006721818.1  zinc transporter ZIP11 isoform X1

    See identical proteins and their annotated locations for XP_006721818.1

    UniProtKB/Swiss-Prot
    Q8N1S5
    Conserved Domains (1) summary
    COG0428
    Location:6342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  5. XM_011524493.1XP_011522795.1  zinc transporter ZIP11 isoform X1

    See identical proteins and their annotated locations for XP_011522795.1

    UniProtKB/Swiss-Prot
    Q8N1S5
    Conserved Domains (1) summary
    COG0428
    Location:6342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  6. XM_017024337.1XP_016879826.1  zinc transporter ZIP11 isoform X4

  7. XM_017024336.2XP_016879825.1  zinc transporter ZIP11 isoform X4

  8. XM_017024334.2XP_016879823.1  zinc transporter ZIP11 isoform X5

    Conserved Domains (1) summary
    COG0428
    Location:6285
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  9. XM_011524494.2XP_011522796.1  zinc transporter ZIP11 isoform X1

    See identical proteins and their annotated locations for XP_011522796.1

    UniProtKB/Swiss-Prot
    Q8N1S5
    Conserved Domains (1) summary
    COG0428
    Location:6342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  10. XM_017024332.1XP_016879821.1  zinc transporter ZIP11 isoform X2

    UniProtKB/Swiss-Prot
    Q8N1S5
    Conserved Domains (1) summary
    COG0428
    Location:6335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  11. XM_017024333.1XP_016879822.1  zinc transporter ZIP11 isoform X4

  12. XM_011524495.3XP_011522797.1  zinc transporter ZIP11 isoform X6

    Conserved Domains (1) summary
    COG0428
    Location:6218
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
  13. XM_017024342.1XP_016879831.1  zinc transporter ZIP11 isoform X14

  14. XM_006721759.1XP_006721822.1  zinc transporter ZIP11 isoform X12

    Conserved Domains (1) summary
    cl00437
    Location:6218
    Zip; ZIP Zinc transporter
  15. XM_006721756.3XP_006721819.1  zinc transporter ZIP11 isoform X3

    Conserved Domains (1) summary
    cl00437
    Location:6218
    Zip; ZIP Zinc transporter
  16. XM_011524498.3XP_011522800.1  zinc transporter ZIP11 isoform X15

    Related
    ENSP00000462200.1, ENST00000580557.5
    Conserved Domains (1) summary
    cl00437
    Location:6102
    Zip; ZIP Zinc transporter
  17. XM_011524496.2XP_011522798.1  zinc transporter ZIP11 isoform X8

    Conserved Domains (1) summary
    cl00437
    Location:6102
    Zip; ZIP Zinc transporter
  18. XM_017024338.1XP_016879827.1  zinc transporter ZIP11 isoform X9

  19. XM_017024339.1XP_016879828.1  zinc transporter ZIP11 isoform X10

  20. XM_017024340.2XP_016879829.1  zinc transporter ZIP11 isoform X13

  21. XM_006721758.4XP_006721821.1  zinc transporter ZIP11 isoform X11

    Conserved Domains (1) summary
    cl00437
    Location:6102
    Zip; ZIP Zinc transporter
  22. XM_017024341.2XP_016879830.1  zinc transporter ZIP11 isoform X13

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