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Rps6 ribosomal protein S6 [ Mus musculus (house mouse) ]

Gene ID: 20104, updated on 31-Jan-2023

Summary

Official Symbol
Rps6provided by MGI
Official Full Name
ribosomal protein S6provided by MGI
Primary source
MGI:MGI:98159
See related
Ensembl:ENSMUSG00000028495 AllianceGenome:MGI:98159
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S6R
Summary
Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of ribosome. Involved in glucose homeostasis. Acts upstream of or within several processes, including T cell activation; activation-induced cell death of T cells; and ribosome biogenesis. Located in dendrite; perinuclear region of cytoplasm; and ribosome. Part of cytosolic small ribosomal subunit and polysome. Is expressed in several structures, including early conceptus; forelimb; gonad; intestine epithelium; and salivary gland. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 484.2), CNS E11.5 (RPKM 432.7) and 25 other tissues See more
Orthologs
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Genomic context

See Rps6 in Genome Data Viewer
Location:
4; 4 C4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86772336..86775604, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86854099..86857367, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4C Neighboring gene predicted gene 6521 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene alkaline ceramidase 2 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 Neighboring gene cadherin-2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC102571, MGC103209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell proliferation involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell proliferation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mammalian oogenesis stage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of polysome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in ribosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
40S ribosomal protein S6
Names
phosphoprotein NP33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009096.3NP_033122.1  40S ribosomal protein S6

    See identical proteins and their annotated locations for NP_033122.1

    Status: PROVISIONAL

    Source sequence(s)
    AK146952
    Consensus CDS
    CCDS18310.1
    UniProtKB/Swiss-Prot
    P10660, P62754
    UniProtKB/TrEMBL
    A0A6P5PLQ8, A0A8C6HJS9, Q5BLK1
    Related
    ENSMUSP00000099878.5, ENSMUST00000102814.5
    Conserved Domains (1) summary
    cl00931
    Location:1215
    Ribosomal_S6e; Ribosomal protein S6e

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    86772336..86775604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)