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Rps24 ribosomal protein S24 [ Mus musculus (house mouse) ]

Gene ID: 20088, updated on 9-Mar-2023

Summary

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Official Symbol
Rps24provided by MGI
Official Full Name
ribosomal protein S24provided by MGI
Primary source
MGI:MGI:98147
See related
Ensembl:ENSMUSG00000025290 AllianceGenome:MGI:98147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable translation initiation factor binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in erythrocyte homeostasis; rRNA processing; and ribosomal small subunit biogenesis. Predicted to act upstream of or within translation. Predicted to be located in cytosolic ribosome and endoplasmic reticulum. Predicted to be part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-blackfan anemia 3. Orthologous to human RPS24 (ribosomal protein S24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 223.6), bladder adult (RPKM 143.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rps24 in Genome Data Viewer
Location:
14; 14 A3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (24540746..24547028)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (24490678..24496960)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47814 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide A Neighboring gene predicted gene, 31720 Neighboring gene predicted gene, 31775 Neighboring gene predicted gene, 31951

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide sequences of a cDNA clone encoding mouse ribosomal protein S24. Ro HS, et al. Nucleic Acids Res, 1991 Dec 11. PMID 1840675, Free PMC Article
  2. Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. Kazerounian S, et al. J Cancer, 2016. PMID 26722357, Free PMC Article
  3. Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs. Xu L, et al. Nucleic Acids Res, 1994 Feb 25. PMID 8127713, Free PMC Article
  4. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. De Arras L, et al. Genetics, 2014 Jun. PMID 24361939, Free PMC Article
  5. The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells. Kondoh N, et al. Biochim Biophys Acta, 1996 Aug 21. PMID 8781548

See all (39) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107549

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in erythrocyte homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
40S ribosomal protein S24
Names
MRP S24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360584.1 → NP_001347513.1  40S ribosomal protein S24 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154573, AK049387, AV005700, BY311117, BY705524, CJ221494
    UniProtKB/TrEMBL
    A0A6P7QK02, Q9D7P1
    Conserved Domains (1) summary
    PTZ00071
    Location:1 → 130
    PTZ00071; 40S ribosomal protein S24; Provisional

  2. NM_001360585.1 → NP_001347514.1  40S ribosomal protein S24 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154573, AK049387, BY311117, BY705524, CJ221494, CX734306
    UniProtKB/TrEMBL
    A0A6P7QHH4, A0A8C6HD02
    Conserved Domains (1) summary
    PTZ00071
    Location:1 → 130
    PTZ00071; 40S ribosomal protein S24; Provisional

  3. NM_001360586.1 → NP_001347515.1  40S ribosomal protein S24 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AK049387, BB680942, BY139840, CJ221494, CX768480
    Consensus CDS
    CCDS88598.1
    UniProtKB/TrEMBL
    A0A286YEB7
    Related
    ENSMUSP00000153637.2, ENSMUST00000224568.2
    Conserved Domains (1) summary
    cl00878
    Location:1 → 118
    Ribosomal_S24e; Ribosomal protein S24e

  4. NM_011297.3 → NP_035427.2  40S ribosomal protein S24 isoform 1

    See identical proteins and their annotated locations for NP_035427.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate segment, which results in the use of an early stop codon, compared to variant 2. The resulting protein (isoform 1) has a shorter C-terminus when compared to isoform 2.
    Source sequence(s)
    AC154573, AK005358, AK049387, BY311117, CJ221494
    Consensus CDS
    CCDS36830.1
    UniProtKB/Swiss-Prot
    P62849
    UniProtKB/TrEMBL
    A0A6P5R564, A0A8C6MX86
    Related
    ENSMUSP00000125977.3, ENSMUST00000169826.3
    Conserved Domains (1) summary
    PTZ00071
    Location:1 → 130
    PTZ00071; 40S ribosomal protein S24; Provisional

  5. NM_207634.2 → NP_997517.1  40S ribosomal protein S24 isoform 2

    See identical proteins and their annotated locations for NP_997517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is the shortest transcript yet it encodes the longest protein (isoform 2).
    Source sequence(s)
    AC154573, AK007776, AK049387, BY311117, CJ221494
    Consensus CDS
    CCDS36829.1
    UniProtKB/Swiss-Prot
    P62849, Q6PDB5
    UniProtKB/TrEMBL
    A0A6P5QSH7, Q5M9M7
    Related
    ENSMUSP00000152944.2, ENSMUST00000225023.2
    Conserved Domains (1) summary
    PTZ00071
    Location:1 → 130
    PTZ00071; 40S ribosomal protein S24; Provisional

  6. NM_207635.2 → NP_997518.1  40S ribosomal protein S24 isoform 3

    See identical proteins and their annotated locations for NP_997518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains two adjacent segments in the coding region, which result in the use of an early stop codon, compared to variant 2. The resulting protein (isoform 3) is shorter when compared to isoform 2.
    Source sequence(s)
    AC154573, AK009048, AK049387, BY311117, CJ221494
    Consensus CDS
    CCDS88597.1
    UniProtKB/Swiss-Prot
    P62849
    UniProtKB/TrEMBL
    A0A6P7QHH4, A0A8C6HD02, Q9D7P1
    Related
    ENSMUSP00000153659.2, ENSMUST00000223999.2
    Conserved Domains (1) summary
    PTZ00071
    Location:1 → 130
    PTZ00071; 40S ribosomal protein S24; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    24540746..24547028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247696.1 → XP_030103556.1  40S ribosomal protein S24 isoform X1

    Conserved Domains (1) summary
    cl00878
    Location:1 → 118
    Ribosomal_S24e; Ribosomal protein S24e
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62849.1 GenPept UniProtKB/Swiss-Prot:P62849

Gene LinkOut

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