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Rps19 ribosomal protein S19 [ Mus musculus (house mouse) ]

Gene ID: 20085, updated on 3-Apr-2024

Summary

Official Symbol
Rps19provided by MGI
Official Full Name
ribosomal protein S19provided by MGI
Primary source
MGI:MGI:1333780
See related
Ensembl:ENSMUSG00000040952 AllianceGenome:MGI:1333780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dsk3
Summary
Predicted to enable several functions, including fibroblast growth factor binding activity; identical protein binding activity; and translation initiation factor binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within Notch signaling pathway. Is active in synapse. Is expressed in early conceptus. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and Diamond-Blackfan anemia 1. Orthologous to human RPS19 (ribosomal protein S19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 234.0), liver E14.5 (RPKM 229.7) and 28 other tissues See more
Orthologs
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Genomic context

See Rps19 in Genome Data Viewer
Location:
7 A3; 7 13.41 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24584013..24589236)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24884592..24889811)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Ly6/Plaur domain containing 4 Neighboring gene doublesex and mab-3 related transcription factor like family C2 Neighboring gene predicted gene, 38966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669208-25669317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25669584-25669693 Neighboring gene STARR-positive B cell enhancer ABC_E10428 Neighboring gene CD79A antigen (immunoglobulin-associated alpha) Neighboring gene STARR-positive B cell enhancer ABC_E1723 Neighboring gene Rho guanine nucleotide exchange factor 1 Neighboring gene CapStarr-seq enhancers MGSCv37_chr7:25692211-25692364 and MGSCv37_chr7:25692403-25692604

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC107694

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
 
involved_in maturation of SSU-rRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of respiratory burst involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleolus organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of respiratory burst involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ribosomal small subunit assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 
part_of small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small ribosomal subunit protein eS19
Names
40S ribosomal protein S19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360115.2NP_001347044.2  small ribosomal subunit protein eS19 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/Swiss-Prot
    Q5M9J4, Q9CZX8
  2. NM_001360116.2NP_001347045.1  small ribosomal subunit protein eS19 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/TrEMBL
    Q5M9P3
    Related
    ENSMUSP00000120774.2, ENSMUST00000156372.8
    Conserved Domains (1) summary
    pfam01090
    Location:16152
    Ribosomal_S19e; Ribosomal protein S19e
  3. NM_001360118.2NP_001347047.1  small ribosomal subunit protein eS19 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS20966.1
    UniProtKB/Swiss-Prot
    Q5M9J4, Q9CZX8
    UniProtKB/TrEMBL
    Q5M9P3
    Related
    ENSMUSP00000114949.3, ENSMUST00000153451.9
    Conserved Domains (1) summary
    pfam01090
    Location:5141
    Ribosomal_S19e; Ribosomal protein S19e
  4. NM_001360119.2NP_001347048.1  small ribosomal subunit protein eS19 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS20966.1
    UniProtKB/Swiss-Prot
    Q5M9J4, Q9CZX8
    UniProtKB/TrEMBL
    Q5M9P3
    Related
    ENSMUSP00000104068.4, ENSMUST00000108430.10
    Conserved Domains (1) summary
    pfam01090
    Location:5141
    Ribosomal_S19e; Ribosomal protein S19e
  5. NM_001360125.2NP_001347054.1  small ribosomal subunit protein eS19 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC161441
    UniProtKB/TrEMBL
    Q5M9P3
    Conserved Domains (1) summary
    pfam01090
    Location:5131
    Ribosomal_S19e; Ribosomal protein S19e
  6. NM_001360128.2NP_001347057.1  small ribosomal subunit protein eS19 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (e) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC161441
    Conserved Domains (1) summary
    cl00969
    Location:571
    Ribosomal_S19e; Ribosomal protein S19e
  7. NM_023133.2NP_075622.1  small ribosomal subunit protein eS19 isoform a

    See identical proteins and their annotated locations for NP_075622.1

    Status: VALIDATED

    Source sequence(s)
    AC161441
    Consensus CDS
    CCDS20966.1
    UniProtKB/Swiss-Prot
    Q5M9J4, Q9CZX8
    UniProtKB/TrEMBL
    Q5M9P3
    Related
    ENSMUSP00000104067.2, ENSMUST00000108429.8
    Conserved Domains (1) summary
    pfam01090
    Location:5141
    Ribosomal_S19e; Ribosomal protein S19e

RNA

  1. NR_153408.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161441
    Related
    ENSMUST00000129847.8
  2. NR_153409.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161441

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24584013..24589236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)