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GKN2 gastrokine 2 [ Homo sapiens (human) ]

Gene ID: 200504, updated on 9-Jun-2025
Official Symbol
GKN2provided by HGNC
Official Full Name
gastrokine 2provided by HGNC
Primary source
HGNC:HGNC:24588
See related
Ensembl:ENSG00000183607 MIM:618589; AllianceGenome:HGNC:24588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDDR; TFIZ1; PRO813; BRICD1B; VLTI465
Summary
The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward stomach (RPKM 1463.9) See more
Orthologs
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See GKN2 in Genome Data Viewer
Location:
2p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68945232..68952893, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68957643..68965305, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (69172364..69180025, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374792 Neighboring gene VISTA enhancer hs2511 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:69134837-69136036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15968 Neighboring gene gastrokine 3, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:69199258-69199490 Neighboring gene gastrokine 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59282 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene microRNA 3126

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within NLRP3 inflammasome complex assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neutrophil activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to bacterium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to cortisol IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to stress IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to wounding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basal part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
gastrokine-2
Names
BRICHOS domain containing 1B
blottin
down-regulated in gastric cancer GDDR
trefoil factor interactions(z) 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182536.3NP_872342.2  gastrokine-2 precursor

    See identical proteins and their annotated locations for NP_872342.2

    Status: REVIEWED

    Source sequence(s)
    AF494509
    Consensus CDS
    CCDS33215.1
    UniProtKB/Swiss-Prot
    Q6UWS6, Q86XP6
    UniProtKB/TrEMBL
    E5RHQ8
    Related
    ENSP00000329292.4, ENST00000328895.9
    Conserved Domains (1) summary
    smart01039
    Location:54150
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    68945232..68952893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    68957643..68965305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)