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GGN gametogenetin [ Homo sapiens (human) ]

Gene ID: 199720, updated on 8-Jul-2021

Summary

Official Symbol
GGNprovided by HGNC
Official Full Name
gametogenetinprovided by HGNC
Primary source
HGNC:HGNC:18869
See related
Ensembl:ENSG00000179168 MIM:609966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 12.5) See more
Orthologs
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Genomic context

See GGN in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38384267..38388603, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38874907..38878674, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11361 Neighboring gene cation channel sperm associated auxiliary subunit gamma Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene sprouty related EVH1 domain containing 3 Neighboring gene family with sequence similarity 98 member C Neighboring gene RAS guanyl releasing protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35713, MGC33369

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
involved_in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152657.4NP_689870.3  gametogenetin

    See identical proteins and their annotated locations for NP_689870.3

    Status: REVIEWED

    Source sequence(s)
    AC005789
    Consensus CDS
    CCDS12516.1
    UniProtKB/Swiss-Prot
    Q86UU5
    Related
    ENSP00000334940.5, ENST00000334928.11
    Conserved Domains (1) summary
    pfam15685
    Location:2652
    GGN; Gametogenetin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38384267..38388603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526603.2XP_011524905.1  gametogenetin isoform X2

    See identical proteins and their annotated locations for XP_011524905.1

    Conserved Domains (1) summary
    pfam15685
    Location:1569
    GGN; Gametogenetin
  2. XM_005258619.4XP_005258676.1  gametogenetin isoform X1

    See identical proteins and their annotated locations for XP_005258676.1

    UniProtKB/Swiss-Prot
    Q86UU5
    Conserved Domains (1) summary
    pfam15685
    Location:2652
    GGN; Gametogenetin
  3. XM_017026451.1XP_016881940.1  gametogenetin isoform X1

    UniProtKB/Swiss-Prot
    Q86UU5
    Conserved Domains (1) summary
    pfam15685
    Location:2652
    GGN; Gametogenetin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182477.1: Suppressed sequence

    Description
    NM_182477.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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