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Mrpl23 mitochondrial ribosomal protein L23 [ Mus musculus (house mouse) ]

Gene ID: 19935, updated on 4-Mar-2023

Summary

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Official Symbol
Mrpl23provided by MGI
Official Full Name
mitochondrial ribosomal protein L23provided by MGI
Primary source
MGI:MGI:1196612
See related
Ensembl:ENSMUSG00000037772 AllianceGenome:MGI:1196612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpl23; L23mrp; Rpl23l
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrial ribosome. Is expressed in several structures, including early conceptus; forelimb bud; genitourinary system; liver; and thymus primordium. Orthologous to human MRPL23 (mitochondrial ribosomal protein L23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.3), bladder adult (RPKM 14.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrpl23 in Genome Data Viewer
Location:
7 F5; 7 87.95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142086204..142094484)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142532467..142540747)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lymphocyte specific 1 Neighboring gene proline rich 33 Neighboring gene troponin T3, skeletal, fast Neighboring gene H19/Igf2 enhancer region Neighboring gene non-coding transcript 1 Neighboring gene microRNA 675 Neighboring gene H19, imprinted maternally expressed transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7. Purbowasito W, et al. DNA Res, 2004 Dec 31. PMID 15871462
  2. The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns. Greally JM, et al. Hum Mol Genet, 1998 Jan. PMID 9384608
  3. Sequence of a 42-kb mouse region containing the imprinted H19 locus: identification of a novel muscle-specific transcription unit showing biallelic expression. Ishihara K, et al. Mamm Genome, 1998 Sep. PMID 9716667
  4. Matrix-attachment regions in the mouse chromosome 7F imprinted domain. Greally JM, et al. Mamm Genome, 1997. PMID 9337391
  5. Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 2000 Jun 16. PMID 10751423

See all (38) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
39S ribosomal protein L23, mitochondrial
Names
L23 mitochondrial-related protein
L23mt
MRP-L23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417208.1 → NP_001404137.1  39S ribosomal protein L23, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC013548, AL603651

  2. NM_001417209.1 → NP_001404138.1  39S ribosomal protein L23, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC013548, AL603651

  3. NM_001417210.1 → NP_001404139.1  39S ribosomal protein L23, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC013548, AL603651

  4. NM_001417211.1 → NP_001404140.1  39S ribosomal protein L23, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC013548, AL603651

  5. NM_011288.3 → NP_035418.1  39S ribosomal protein L23, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_035418.1

    Status: VALIDATED

    Source sequence(s)
    AC013548, AL603651
    Consensus CDS
    CCDS22032.1
    UniProtKB/Swiss-Prot
    O35972, Q78E46
    Related
    ENSMUSP00000039784.7, ENSMUST00000038675.7
    Conserved Domains (1) summary
    pfam00276
    Location:42 → 105
    Ribosomal_L23; Ribosomal protein L23

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142086204..142094484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322050.2 → XP_017177539.1  39S ribosomal protein L23, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam00276
    Location:67 → 132
    Ribosomal_L23; Ribosomal protein L23

  2. XM_006508518.5 → XP_006508581.1  39S ribosomal protein L23, mitochondrial isoform X4

    Related
    ENSMUSP00000147311.2, ENSMUST00000210803.2
    Conserved Domains (1) summary
    pfam00276
    Location:8 → 66
    Ribosomal_L23; Ribosomal protein L23

  3. XM_006508516.5 → XP_006508579.1  39S ribosomal protein L23, mitochondrial isoform X2

    Related
    ENSMUSP00000148138.2, ENSMUST00000210662.2
    Conserved Domains (1) summary
    pfam00276
    Location:40 → 105
    Ribosomal_L23; Ribosomal protein L23

  4. XM_006508517.3 → XP_006508580.1  39S ribosomal protein L23, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam00276
    Location:38 → 103
    Ribosomal_L23; Ribosomal protein L23
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35972.1 GenPept UniProtKB/Swiss-Prot:O35972

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