Rpia ribose 5-phosphate isomerase A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpiaprovided by MGI
Official Full Name: ribose 5-phosphate isomerase Aprovided by MGI
Primary source: MGI:MGI:103254
See related: Ensembl:ENSMUSG00000053604 AllianceGenome:MGI:103254
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RPI
Summary: Enables ribose-5-phosphate isomerase activity. Predicted to be involved in D-ribose metabolic process; pentose-phosphate shunt, non-oxidative branch; and ribose phosphate metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in alimentary system; liver; lung; and respiratory system. Orthologous to human RPIA (ribose 5-phosphate isomerase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 26.2), liver E14.5 (RPKM 22.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.06 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (70742704..70769159, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (70765720..70792175, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study provides new insight into the molecular mechanisms by which RPIA overexpression can induce oncogenesis in hepatocellular carcinoma.
Title: Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU017435 (e-PCR)
- UniSTS:207976

RPIA (e-PCR)
- UniSTS:505025

Homology

Homologs of the Rpia gene: The Rpia gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 492 organisms have orthologs with human gene Rpia
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	ISO Inferred from Sequence Orthology more info
enables ribose-5-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ribose-5-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribose-5-phosphate isomerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-ribose metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in pentose-phosphate shunt	IDA Inferred from Direct Assay more info	PubMed
involved_in pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, non-oxidative branch	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in pentose-phosphate shunt, non-oxidative branch	ISO Inferred from Sequence Orthology more info
involved_in ribose phosphate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribose-5-phosphate isomerase

Names: phosphoriboisomerase

NP_033101.2

EC 5.3.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009075.2 → NP_033101.2 ribose-5-phosphate isomerase

See identical proteins and their annotated locations for NP_033101.2

Status: VALIDATED

Source sequence(s)

AC156398, AK137235, CO043650

Consensus CDS

CCDS39504.1

UniProtKB/Swiss-Prot

P47968, Q3UVI8

UniProtKB/TrEMBL

A0A8C6HHL5

Related

ENSMUSP00000064158.6, ENSMUST00000066134.6

Conserved Domains (1) summary

cd01398
Location:74 → 291

RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...