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Rpia ribose 5-phosphate isomerase A [ Mus musculus (house mouse) ]

Gene ID: 19895, updated on 8-Feb-2024

Summary

Official Symbol
Rpiaprovided by MGI
Official Full Name
ribose 5-phosphate isomerase Aprovided by MGI
Primary source
MGI:MGI:103254
See related
Ensembl:ENSMUSG00000053604 AllianceGenome:MGI:103254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPI
Summary
Enables ribose-5-phosphate isomerase activity. Predicted to be involved in D-ribose metabolic process; pentose-phosphate shunt, non-oxidative branch; and ribose phosphate metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in alimentary system; liver; lung; and respiratory system. Orthologous to human RPIA (ribose 5-phosphate isomerase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 26.2), liver E14.5 (RPKM 22.8) and 27 other tissues See more
Orthologs
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Genomic context

See Rpia in Genome Data Viewer
Location:
6 C1; 6 32.06 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (70742704..70769159, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (70765720..70792175, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin kappa chain complex Neighboring gene STARR-positive B cell enhancer ABC_E11318 Neighboring gene STARR-positive B cell enhancer ABC_E2193 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70694043-70694344 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70702533-70702834 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70712736-70712889 Neighboring gene STARR-seq mESC enhancer starr_16238 Neighboring gene STARR-positive B cell enhancer ABC_E6436 Neighboring gene STARR-seq mESC enhancer starr_16241 Neighboring gene STARR-positive B cell enhancer mm9_chr6:70761912-70762213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70764223-70764410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70765584-70765767 Neighboring gene STARR-seq mESC enhancer starr_16242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:70779525-70779708 Neighboring gene predicted gene, 30211 Neighboring gene predicted gene, 30331 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 3 Neighboring gene predicted gene, 23346 Neighboring gene immunoglobulin kappa constant

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables ribose-5-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribose-5-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribose-5-phosphate isomerase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in D-ribose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pentose-phosphate shunt, non-oxidative branch ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribose-5-phosphate isomerase
Names
phosphoriboisomerase
NP_033101.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009075.2NP_033101.2  ribose-5-phosphate isomerase

    See identical proteins and their annotated locations for NP_033101.2

    Status: VALIDATED

    Source sequence(s)
    AC156398, AK137235, CO043650
    Consensus CDS
    CCDS39504.1
    UniProtKB/Swiss-Prot
    P47968, Q3UVI8
    Related
    ENSMUSP00000064158.6, ENSMUST00000066134.6
    Conserved Domains (1) summary
    cd01398
    Location:74291
    RPI_A; RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    70742704..70769159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)