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mt:CoII mitochondrial Cytochrome c oxidase subunit II [ Drosophila melanogaster (fruit fly) ]

Gene ID: 19893535, updated on 18-Sep-2024

Summary

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Official Symbol
mt:CoIIprovided by FlyBase
Official Full Name
mitochondrial Cytochrome c oxidase subunit IIprovided by FlyBase
Primary source
FLYBASE:FBgn0013675
Locus tag
Dmel_CG34069
See related
AllianceGenome:FB:FBgn0013675
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
mt:CoII; COX2
Summary
Predicted to enable copper ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be integral component of membrane. Predicted to be part of mitochondrial respiratory chain complex IV. Is expressed in adult head and spermatozoon. Orthologous to several human genes including MTCO2P12 (MT-CO2 pseudogene 12). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) MT (non-nuclear) NC_024511.2 (3083..3767)

Chromosome MT - NC_024511.2Genomic Context describing neighboring genes Neighboring gene mitochondrial Cytochrome c oxidase subunit I Neighboring gene mitochondrial transfer RNA:Leucine-TAA Neighboring gene mitochondrial transfer RNA:Lysine-CTT Neighboring gene mitochondrial transfer RNA:Aspartic acid-GTC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_024511.2 Chromosome MT Reference Release 6 plus ISO1 MT non-nuclear

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Precise annotation of Drosophila mitochondrial genomes leads to insights into AT-rich regions. Liang G, et al. Mitochondrion, 2022 Jul. PMID 35779797
  2. Mitonuclear Interactions Produce Diverging Responses to Mild Stress in Drosophila Larvae. Rodríguez E, et al. Front Genet, 2021. PMID 34603395, Free PMC Article
  3. A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster. Patel MR, et al. Elife, 2016 Aug 2. PMID 27481326, Free PMC Article
  4. DNA barcoding of recently diverged species: relative performance of matching methods. van Velzen R, et al. PLoS One, 2012. PMID 22272356, Free PMC Article
  5. Quakes hit California and, perhaps, the central dogma. Jukes TH. J Mol Evol, 1990 Jan. PMID 2107320

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytochrome-c oxidase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to cytochrome-c oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit II
YP_009047268.1
  • TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_024511.2 Reference assembly

    Range
    3083..3767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009047268.1 Peptide Sequence

    See identical proteins and their annotated locations for YP_009047268.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B2L9S3, B6E0V9, P00408, Q05GI7
    UniProtKB/TrEMBL
    A0A0A0RZ60, C6KI54, J9THZ9, J9TIE4
    Related
    FBpp0100177
    Conserved Domains (1) summary
    MTH00154
    Location:1 → 227
    COX2; cytochrome c oxidase subunit II; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00408.1 P00408

Gene LinkOut

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