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Rnps1 RNA binding protein with serine rich domain 1 [ Mus musculus (house mouse) ]

Gene ID: 19826, updated on 27-Feb-2024

Summary

Official Symbol
Rnps1provided by MGI
Official Full Name
RNA binding protein with serine rich domain 1provided by MGI
Primary source
MGI:MGI:97960
See related
Ensembl:ENSMUSG00000034681 AllianceGenome:MGI:97960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of apoptotic process; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in central nervous system; sensory organ; thymus; and tooth. Orthologous to human RNPS1 (RNA binding protein with serine rich domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.5), CNS E14 (RPKM 86.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rnps1 in Genome Data Viewer
Location:
17 A3.3; 17 12.39 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24633620..24644872)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24414646..24425898)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene predicted gene, 25618 Neighboring gene STARR-seq mESC enhancer starr_42084 Neighboring gene RIKEN cDNA D330041H03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3188 Neighboring gene enoyl-Coenzyme A delta isomerase 1 Neighboring gene deoxyribonuclease 1-like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ASAP complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RNA-binding protein with serine-rich domain 1
Names
ribonucleic acid binding protein S1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080127.1NP_001073596.1  RNA-binding protein with serine-rich domain 1 isoform 1

    See identical proteins and their annotated locations for NP_001073596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AK151150, BX526195, CJ058744
    Consensus CDS
    CCDS37488.1
    UniProtKB/Swiss-Prot
    Q3TMJ1, Q922H8, Q99M28
    Related
    ENSMUSP00000085867.6, ENSMUST00000088512.13
    Conserved Domains (1) summary
    cd12365
    Location:163236
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins
  2. NM_001080128.1NP_001073597.1  RNA-binding protein with serine-rich domain 1 isoform 2

    See identical proteins and their annotated locations for NP_001073597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 5' region, which results in an alternate translation start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK165905, BX526195, BY013195
    Consensus CDS
    CCDS37487.1
    UniProtKB/Swiss-Prot
    Q99M28
    Related
    ENSMUSP00000111028.2, ENSMUST00000115371.9
    Conserved Domains (1) summary
    cd12365
    Location:140213
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins
  3. NM_001357626.1NP_001344555.1  RNA-binding protein with serine-rich domain 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC154237, BQ174147
    Consensus CDS
    CCDS37488.1
    UniProtKB/Swiss-Prot
    Q3TMJ1, Q922H8, Q99M28
    Conserved Domains (1) summary
    cd12365
    Location:163236
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins
  4. NM_009070.2NP_033096.2  RNA-binding protein with serine-rich domain 1 isoform 1

    See identical proteins and their annotated locations for NP_033096.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AK151150, BB868062, BX526195
    Consensus CDS
    CCDS37488.1
    UniProtKB/Swiss-Prot
    Q3TMJ1, Q922H8, Q99M28
    Related
    ENSMUSP00000126345.2, ENSMUST00000163717.2
    Conserved Domains (1) summary
    cd12365
    Location:163236
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24633620..24644872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)