Format

Send to:

Choose Destination

EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 [ Homo sapiens (human) ]

Gene ID: 1979, updated on 27-Jan-2020

Summary

Official Symbol
EIF4EBP2provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4E binding protein 2provided by HGNC
Primary source
HGNC:HGNC:3289
See related
Ensembl:ENSG00000148730 MIM:602224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4EBP2; PHASII
Summary
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in fat (RPKM 50.2), kidney (RPKM 34.8) and 25 other tissues See more
Orthologs

Genomic context

See EIF4EBP2 in Genome Data Viewer
Location:
10q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70404145..70428618)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (72163861..72188374)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 20 Neighboring gene centrosomal protein 57 like 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 10859 Neighboring gene nodal growth differentiation factor Neighboring gene phosphatase domain containing paladin 1 Neighboring gene YY1 transcription factor pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
eukaryotic initiation factor 4E binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic initiation factor 4E binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
memory ISS
Inferred from Sequence or Structural Similarity
more info
 
modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
social behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E-binding protein 2
Names
4E-BP2
eIF4E-binding protein 2
phosphorylated, heat and acid stable regulated by insulin protein II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004096.5NP_004087.1  eukaryotic translation initiation factor 4E-binding protein 2

    See identical proteins and their annotated locations for NP_004087.1

    Status: REVIEWED

    Source sequence(s)
    AC022532, BC050633, BG717474
    Consensus CDS
    CCDS7303.1
    UniProtKB/Swiss-Prot
    Q13542
    UniProtKB/TrEMBL
    A0A024QZM3
    Related
    ENSP00000362314.4, ENST00000373218.5
    Conserved Domains (1) summary
    pfam05456
    Location:13120
    eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70404145..70428618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center