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Rhd Rh blood group, D antigen [ Mus musculus (house mouse) ]

Gene ID: 19746, updated on 12-May-2024

Summary

Official Symbol
Rhdprovided by MGI
Official Full Name
Rh blood group, D antigenprovided by MGI
Primary source
MGI:MGI:1202882
See related
Ensembl:ENSMUSG00000028825 AllianceGenome:MGI:1202882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rh; Rhl1; Rhced
Summary
Predicted to enable ammonium transmembrane transporter activity. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal iron ion homeostasis. Located in membrane. Is expressed in several structures, including liver; lung; metanephros; secondary oocyte; and spleen. Human ortholog(s) of this gene implicated in Rh isoimmunization. Orthologous to several human genes including RHD (Rh blood group D antigen). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14.5 (RPKM 179.9), liver E14 (RPKM 141.9) and 2 other tissues See more
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Genomic context

See Rhd in Genome Data Viewer
Location:
4 D3; 4 67.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134591875..134623483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134864536..134896172)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3527 Neighboring gene STARR-seq mESC enhancer starr_11687 Neighboring gene STARR-seq mESC enhancer starr_11688 Neighboring gene macoilin 1 Neighboring gene STARR-positive B cell enhancer ABC_E2718 Neighboring gene STARR-positive B cell enhancer ABC_E4682 Neighboring gene STARR-seq mESC enhancer starr_11693 Neighboring gene transmembrane protein 50A Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134474397-134474585 Neighboring gene STARR-positive B cell enhancer ABC_E6231 Neighboring gene STARR-positive B cell enhancer ABC_E8812 Neighboring gene arginine/serine rich protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ammonium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of ankyrin-1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
blood group Rh(D) polypeptide
Names
Rh blood group protein
Rh-like polypeptide
Rhesus blood group CE and D
erythrocyte membrane glycoprotein Rh30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011270.4NP_035400.3  blood group Rh(D) polypeptide

    See identical proteins and their annotated locations for NP_035400.3

    Status: VALIDATED

    Source sequence(s)
    AL611963
    Consensus CDS
    CCDS18778.1
    UniProtKB/Swiss-Prot
    O88296, O88297, Q8CF94, Q9QUM6, Q9QX04
    UniProtKB/TrEMBL
    A0A0R4J0A2
    Related
    ENSMUSP00000030627.8, ENSMUST00000030627.8
    Conserved Domains (1) summary
    cl03012
    Location:53393
    Ammonium_transp; Ammonium Transporter Family

RNA

  1. NR_188963.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611963

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134591875..134623483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)