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PATL2 PAT1 homolog 2 [ Homo sapiens (human) ]

Gene ID: 197135, updated on 21-Dec-2019

Summary

Official Symbol
PATL2provided by HGNC
Official Full Name
PAT1 homolog 2provided by HGNC
Primary source
HGNC:HGNC:33630
See related
Ensembl:ENSG00000229474 MIM:614661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OOMD4; Pat1a; hPat1a
Expression
Broad expression in spleen (RPKM 2.6), lymph node (RPKM 2.5) and 20 other tissues See more
Orthologs

Genomic context

See PATL2 in Genome Data Viewer
Location:
15q21.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (44665732..44711406, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44957930..44970894, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene EIF3J divergent transcript Neighboring gene eukaryotic translation initiation factor 3 subunit J Neighboring gene SPG11 vesicle trafficking associated, spatacsin Neighboring gene ring finger protein 4 pseudogene Neighboring gene microRNA 10393 Neighboring gene beta-2-microglobulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytoplasmic mRNA processing body assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cytoplasmic mRNA processing body assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein PAT1 homolog 2
Names
PAT1-like protein 2
protein PAT1 homolog a
protein associated with topoisomerase II homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145112.1NP_001138584.1  protein PAT1 homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001138584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC009996, AW138454, BI835136, BI909158, DN831868, DR007980
    Consensus CDS
    CCDS45253.1
    UniProtKB/Swiss-Prot
    C9JE40
    Related
    ENSP00000416673.1, ENST00000434130.5
    Conserved Domains (1) summary
    pfam09770
    Location:263397
    PAT1; Topoisomerase II-associated protein PAT1
  2. NM_001330283.1NP_001317212.1  protein PAT1 homolog 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AW138454, BC036924
    Consensus CDS
    CCDS81873.1
    UniProtKB/TrEMBL
    H0YMQ2
    Related
    ENSP00000453695.1, ENST00000560780.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    44665732..44711406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521340.3XP_011519642.1  protein PAT1 homolog 2 isoform X4

    See identical proteins and their annotated locations for XP_011519642.1

    Conserved Domains (1) summary
    pfam09770
    Location:263403
    PAT1; Topoisomerase II-associated protein PAT1
  2. XM_011521339.3XP_011519641.1  protein PAT1 homolog 2 isoform X4

    See identical proteins and their annotated locations for XP_011519641.1

    Conserved Domains (1) summary
    pfam09770
    Location:263403
    PAT1; Topoisomerase II-associated protein PAT1
  3. XM_011521345.3XP_011519647.1  protein PAT1 homolog 2 isoform X7

    Conserved Domains (1) summary
    pfam09770
    Location:176316
    PAT1; Topoisomerase II-associated protein PAT1
  4. XM_011521343.3XP_011519645.1  protein PAT1 homolog 2 isoform X6

    See identical proteins and their annotated locations for XP_011519645.1

    Conserved Domains (1) summary
    pfam09770
    Location:179313
    PAT1; Topoisomerase II-associated protein PAT1
  5. XM_011521338.3XP_011519640.1  protein PAT1 homolog 2 isoform X4

    See identical proteins and their annotated locations for XP_011519640.1

    Conserved Domains (1) summary
    pfam09770
    Location:263403
    PAT1; Topoisomerase II-associated protein PAT1
  6. XM_011521337.2XP_011519639.2  protein PAT1 homolog 2 isoform X2

  7. XM_011521346.2XP_011519648.2  protein PAT1 homolog 2 isoform X8

  8. XM_011521336.2XP_011519638.2  protein PAT1 homolog 2 isoform X1

  9. XM_017022000.2XP_016877489.1  protein PAT1 homolog 2 isoform X3

  10. XM_011521347.1XP_011519649.1  protein PAT1 homolog 2 isoform X9

    Conserved Domains (1) summary
    pfam09770
    Location:74214
    PAT1; Topoisomerase II-associated protein PAT1
  11. XM_011521341.1XP_011519643.1  protein PAT1 homolog 2 isoform X4

    See identical proteins and their annotated locations for XP_011519643.1

    Conserved Domains (1) summary
    pfam09770
    Location:263403
    PAT1; Topoisomerase II-associated protein PAT1
  12. XM_011521342.2XP_011519644.1  protein PAT1 homolog 2 isoform X5

    Conserved Domains (1) summary
    pfam09770
    Location:189329
    PAT1; Topoisomerase II-associated protein PAT1
  13. XM_011521344.3XP_011519646.1  protein PAT1 homolog 2 isoform X6

    See identical proteins and their annotated locations for XP_011519646.1

    Conserved Domains (1) summary
    pfam09770
    Location:179313
    PAT1; Topoisomerase II-associated protein PAT1
  14. XM_017022001.2XP_016877490.1  protein PAT1 homolog 2 isoform X7

    Conserved Domains (1) summary
    pfam09770
    Location:176316
    PAT1; Topoisomerase II-associated protein PAT1
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