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Ret ret proto-oncogene [ Mus musculus (house mouse) ]

Gene ID: 19713, updated on 8-Feb-2024

Summary

Official Symbol
Retprovided by MGI
Official Full Name
ret proto-oncogeneprovided by MGI
Primary source
MGI:MGI:97902
See related
Ensembl:ENSMUSG00000030110 AllianceGenome:MGI:97902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTC; RET9; RET51; c-Ret
Summary
Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including Peyer's patch morphogenesis; neuron cell-cell adhesion; and positive regulation of metanephric glomerulus development. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including endosome; membrane raft; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (ret proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 5.3), subcutaneous fat pad adult (RPKM 4.5) and 18 other tissues See more
Orthologs
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Genomic context

See Ret in Genome Data Viewer
Location:
6 F1; 6 55.86 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (118128709..118174705, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118151748..118197744, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RasGEF domain family, member 1A Neighboring gene microRNA 7044 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene predicted gene, 23908 Neighboring gene STARR-positive B cell enhancer ABC_E6475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:118117270-118117379 Neighboring gene STARR-positive B cell enhancer ABC_E2800 Neighboring gene STARR-seq mESC enhancer starr_17135 Neighboring gene RIKEN cDNA 1700069P05 gene Neighboring gene predicted gene, 30557

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Peyer's patch morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic epithelial tube formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within enteric nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell-derived neurotrophic factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in innervation ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of metanephric glomerulus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ureter maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of plasma membrane protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
proto-oncogene tyrosine-protein kinase receptor Ret
Names
proto-oncogene c-Ret
NP_001074249.1
NP_033076.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080780.1NP_001074249.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor

    See identical proteins and their annotated locations for NP_001074249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longer transcript but encodes the shorter isoform (c). This isoform is also known as Ret9.
    Source sequence(s)
    AC135861, AC156396, BC059012
    Consensus CDS
    CCDS39608.1
    UniProtKB/Swiss-Prot
    P35546
    Related
    ENSMUSP00000086169.4, ENSMUST00000088790.9
    Conserved Domains (3) summary
    cd05045
    Location:7241013
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    pfam00028
    Location:173262
    Cadherin; Cadherin domain
    pfam07714
    Location:7251006
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_009050.2NP_033076.2  proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

    See identical proteins and their annotated locations for NP_033076.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region, compared to variant 4. The resulting protein (isoform a) has a longer, distinct C-terminus compared to isoform c. This isoform is also known as Ret51.
    Source sequence(s)
    AC135861, AC156396, BC059012
    Consensus CDS
    CCDS20470.1
    UniProtKB/Swiss-Prot
    P35546, Q8BQ34, Q9QXH9
    Related
    ENSMUSP00000032201.6, ENSMUST00000032201.8
    Conserved Domains (5) summary
    cd05045
    Location:7241013
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    pfam00028
    Location:173262
    Cadherin; Cadherin domain
    pfam17756
    Location:29154
    RET_CLD1; RET Cadherin like domain 1
    pfam17812
    Location:266380
    RET_CLD3; RET Cadherin like domain 3
    pfam17813
    Location:409508
    RET_CLD4; RET Cadherin like domain 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    118128709..118174705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)