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Reln reelin [ Mus musculus (house mouse) ]

Gene ID: 19699, updated on 1-Oct-2019

Summary

Official Symbol
Relnprovided by MGI
Official Full Name
reelinprovided by MGI
Primary source
MGI:MGI:103022
See related
Ensembl:ENSMUSG00000042453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rl; reeler
Expression
Broad expression in cerebellum adult (RPKM 15.8), CNS E18 (RPKM 13.9) and 17 other tissues See more
Orthologs

Genomic context

See Reln in Genome Data Viewer
Location:
5 A3; 5 9.98 cM
Exon count:
65
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21884454..22344705, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (21390272..21850523, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene solute carrier family 26, member 5 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene predicted gene, 42223 Neighboring gene origin recognition complex, subunit 5 Neighboring gene ribosomal protein L22 like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
    Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
    Lipoprotein metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Reelin signalling pathway, organism-specific biosystem (from REACTOME)
    Reelin signalling pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VLDL interactions, organism-specific biosystem (from REACTOME)
    VLDL interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NMDA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
associative learning IDA
Inferred from Direct Assay
more info
PubMed 
associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis involved in differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex tangential migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dentate gyrus development ISO
Inferred from Sequence Orthology
more info
 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IDA
Inferred from Direct Assay
more info
PubMed 
lateral motor column neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
layer formation in cerebral cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
long-term memory IDA
Inferred from Direct Assay
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of AMPA receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lateral motor column neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic density assembly IC
Inferred by Curator
more info
PubMed 
postsynaptic density protein 95 clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
reelin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 
ventral spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
reelin
Names
extracellular matrix serine protease

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310464.1NP_001297393.1  reelin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC113028, AC116404, AC119906, AC121878
    Consensus CDS
    CCDS80217.1
    UniProtKB/Swiss-Prot
    Q60841
    Related
    ENSMUSP00000058025.7, ENSMUST00000062372.13
    Conserved Domains (20) summary
    cd10036
    Location:203352
    Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
    cd10037
    Location:527672
    Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10038
    Location:8681035
    Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10039
    Location:12411410
    Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10040
    Location:16061775
    Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10041
    Location:19602131
    Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10042
    Location:23232479
    Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10043
    Location:26702854
    Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10044
    Location:30563230
    Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cd10045
    Location:709863
    Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10046
    Location:10661221
    Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10047
    Location:14481598
    Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10048
    Location:18011938
    Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10049
    Location:21662315
    Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10050
    Location:25152662
    Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10051
    Location:28903051
    Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10052
    Location:32673427
    Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cl15240
    Location:422557
    Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
    cd08544
    Location:49179
    Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
    pfam07974
    Location:21312160
    EGF_2; EGF-like domain
  2. NM_011261.2NP_035391.2  reelin isoform 1 precursor

    See identical proteins and their annotated locations for NP_035391.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC113028, AC116404, AC119906, AC121878
    Consensus CDS
    CCDS39023.1
    UniProtKB/Swiss-Prot
    Q60841
    Related
    ENSMUSP00000124052.1, ENSMUST00000161356.7
    Conserved Domains (20) summary
    cd10036
    Location:203352
    Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
    cd10037
    Location:527672
    Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10038
    Location:8681035
    Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10039
    Location:12411410
    Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10040
    Location:16061775
    Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10041
    Location:19602131
    Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10042
    Location:23232479
    Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10043
    Location:26702854
    Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10044
    Location:30563230
    Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cd10045
    Location:709863
    Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10046
    Location:10661221
    Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10047
    Location:14481598
    Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10048
    Location:18011938
    Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10049
    Location:21662315
    Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10050
    Location:25152662
    Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10051
    Location:28903051
    Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10052
    Location:32673427
    Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cl15240
    Location:422557
    Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
    cd08544
    Location:49179
    Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
    pfam07974
    Location:21312160
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p6 C57BL/6J

    Range
    21884454..22344705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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