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Reln reelin [ Mus musculus (house mouse) ]

Gene ID: 19699, updated on 18-Apr-2024

Summary

Official Symbol
Relnprovided by MGI
Official Full Name
reelinprovided by MGI
Primary source
MGI:MGI:103022
See related
Ensembl:ENSMUSG00000042453 AllianceGenome:MGI:103022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rl; reeler
Summary
Enables very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including positive regulation of cell communication; postsynaptic membrane organization; and regulation of neurotransmitter receptor activity. Acts upstream of or within several processes, including nervous system development; peptidyl-tyrosine phosphorylation; and thyroid hormone metabolic process. Located in several cellular components, including dendrite; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; and familial temporal lobe epilepsy 7. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 15.8), CNS E18 (RPKM 13.9) and 17 other tissues See more
Orthologs
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Genomic context

Location:
5 A3; 5 9.98 cM
Exon count:
65
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22089452..22549703, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21884454..22344705, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene solute carrier family 26, member 5 Neighboring gene STARR-seq mESC enhancer starr_12580 Neighboring gene STARR-seq mESC enhancer starr_12582 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene 10475 Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene Neighboring gene predicted gene, 57737 Neighboring gene predicted gene, 54324 Neighboring gene STARR-seq mESC enhancer starr_12584 Neighboring gene predicted gene, 42223 Neighboring gene predicted gene, 25459 Neighboring gene STARR-seq mESC enhancer starr_12585 Neighboring gene STARR-seq mESC enhancer starr_12586 Neighboring gene origin recognition complex, subunit 5 Neighboring gene ribosomal protein L22 like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables very-low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NMDA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in associative learning IDA
Inferred from Direct Assay
more info
PubMed 
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex tangential migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dentate gyrus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hippocampus development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within interneuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lateral motor column neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within layer formation in cerebral cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within motor neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of AMPA receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of CREB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TOR signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lateral motor column neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic density assembly IC
Inferred by Curator
more info
PubMed 
involved_in postsynaptic density protein 95 clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reelin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reelin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of neuron migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic activity NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thyroid hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 
involved_in ventral spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
part_of reelin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
reelin
Names
extracellular matrix serine protease

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310464.1NP_001297393.1  reelin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC113028, AC116404, AC119906, AC121878
    Consensus CDS
    CCDS80217.1
    UniProtKB/Swiss-Prot
    Q60841
    Related
    ENSMUSP00000058025.8, ENSMUST00000062372.14
    Conserved Domains (20) summary
    cd10036
    Location:203352
    Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
    cd10037
    Location:527672
    Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10038
    Location:8681035
    Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10039
    Location:12411410
    Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10040
    Location:16061775
    Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10041
    Location:19602131
    Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10042
    Location:23232479
    Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10043
    Location:26702854
    Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10044
    Location:30563230
    Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cd10045
    Location:709863
    Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10046
    Location:10661221
    Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10047
    Location:14481598
    Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10048
    Location:18011938
    Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10049
    Location:21662315
    Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10050
    Location:25152662
    Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10051
    Location:28903051
    Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10052
    Location:32673427
    Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cl15240
    Location:422557
    Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
    cd08544
    Location:49179
    Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
    pfam07974
    Location:21312160
    EGF_2; EGF-like domain
  2. NM_011261.2NP_035391.2  reelin isoform 1 precursor

    See identical proteins and their annotated locations for NP_035391.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC113028, AC116404, AC119906, AC121878
    Consensus CDS
    CCDS39023.1
    UniProtKB/Swiss-Prot
    E9PZ78, Q60841, Q9CUA6
    Related
    ENSMUSP00000124052.2, ENSMUST00000161356.8
    Conserved Domains (20) summary
    cd10036
    Location:203352
    Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
    cd10037
    Location:527672
    Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10038
    Location:8681035
    Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10039
    Location:12411410
    Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10040
    Location:16061775
    Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10041
    Location:19602131
    Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10042
    Location:23232479
    Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10043
    Location:26702854
    Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10044
    Location:30563230
    Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cd10045
    Location:709863
    Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
    cd10046
    Location:10661221
    Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
    cd10047
    Location:14481598
    Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
    cd10048
    Location:18011938
    Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
    cd10049
    Location:21662315
    Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
    cd10050
    Location:25152662
    Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
    cd10051
    Location:28903051
    Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
    cd10052
    Location:32673427
    Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
    cl15240
    Location:422557
    Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
    cd08544
    Location:49179
    Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins
    pfam07974
    Location:21312160
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    22089452..22549703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)