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Rdh5 retinol dehydrogenase 5 [ Mus musculus (house mouse) ]

Gene ID: 19682, updated on 11-Apr-2024

Summary

Official Symbol
Rdh5provided by MGI
Official Full Name
retinol dehydrogenase 5provided by MGI
Primary source
MGI:MGI:1201412
See related
Ensembl:ENSMUSG00000025350 AllianceGenome:MGI:1201412
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RDH4; cRDH; 9-cis
Summary
Enables NAD-retinol dehydrogenase activity. Involved in retinoid metabolic process. Located in endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 27.1), duodenum adult (RPKM 13.1) and 26 other tissues See more
Orthologs
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Genomic context

Location:
10 D3; 10 77.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128749457..128755906, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128913588..128920037, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 11 Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene CD63 antigen Neighboring gene STARR-positive B cell enhancer ABC_E6941 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene integrin alpha 7 Neighboring gene predicted gene, 25494 Neighboring gene thiol methyltransferase 1B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-cis-retinol dehydrogenase IEA
Inferred from Electronic Annotation
more info
 
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retinoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinol dehydrogenase 5
Names
11-cis RDH
11-cis RoDH
11-cis retinol dehydrogenase
9-cis-retinol dehydrogenase
cis-retinol dehydrogenase
retinol dehydrogenase type 5
NP_001345456.1
NP_598767.1
XP_006513448.1
XP_036011599.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358527.2NP_001345456.1  retinol dehydrogenase 5 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24298.1
    UniProtKB/Swiss-Prot
    O55240
    Conserved Domains (1) summary
    cl25409
    Location:30306
    SDR; Short-chain dehydrogenases/reductases (SDR)
  2. NM_001428782.1NP_001415711.1  retinol dehydrogenase 5 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes the longest isoform (a).
    Source sequence(s)
    AC122380
  3. NM_001428783.1NP_001415712.1  retinol dehydrogenase 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC122380
  4. NM_001428784.1NP_001415713.1  retinol dehydrogenase 5 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC122380
  5. NM_134006.6NP_598767.1  retinol dehydrogenase 5 isoform b

    See identical proteins and their annotated locations for NP_598767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24298.1
    UniProtKB/Swiss-Prot
    O55240
    Related
    ENSMUSP00000026406.8, ENSMUST00000026406.14
    Conserved Domains (1) summary
    cl25409
    Location:30306
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128749457..128755906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513385.4XP_006513448.1  retinol dehydrogenase 5 isoform X1

    See identical proteins and their annotated locations for XP_006513448.1

    Conserved Domains (1) summary
    cl21454
    Location:30308
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_036155706.1XP_036011599.1  retinol dehydrogenase 5 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:30308
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_003948629.1 RNA Sequence