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Rb1 RB transcriptional corepressor 1 [ Mus musculus (house mouse) ]

Gene ID: 19645, updated on 12-Feb-2024

Summary

Official Symbol
Rb1provided by MGI
Official Full Name
RB transcriptional corepressor 1provided by MGI
Primary source
MGI:MGI:97874
See related
Ensembl:ENSMUSG00000022105 AllianceGenome:MGI:97874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rb; pRb; Rb-1; pp105; p110-RB1
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and enzyme binding activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of myofibroblast differentiation; and negative regulation of transcription involved in G1/S transition of mitotic cell cycle. Acts upstream of or within several processes, including hepatocyte apoptotic process; neuron development; and regulation of transcription by RNA polymerase II. Located in nucleus and spindle. Part of Rb-E2F complex. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; retina; and vibrissa. Human ortholog(s) of this gene implicated in nervous system cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder cancer. Orthologous to human RB1 (RB transcriptional corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 8.6), whole brain E14.5 (RPKM 8.3) and 24 other tissues See more
Orthologs
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Genomic context

See Rb1 in Genome Data Viewer
Location:
14 38.73 cM; 14 D3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73430298..73563446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73192858..73325951, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73516811-73517104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73518865-73519018 Neighboring gene predicted gene, 35388 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 Neighboring gene STARR-seq mESC enhancer starr_37111 Neighboring gene predicted gene, 52109 Neighboring gene STARR-seq mESC enhancer starr_37112 Neighboring gene VISTA enhancer mm1341 Neighboring gene microRNA 687 Neighboring gene STARR-seq mESC enhancer starr_37114 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene STARR-seq mESC enhancer starr_37116 Neighboring gene STARR-positive B cell enhancer ABC_E9900 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:73788957-73789140 Neighboring gene integral membrane protein 2B Neighboring gene STARR-positive B cell enhancer ABC_E7335 Neighboring gene STARR-seq mESC enhancer starr_37118 Neighboring gene STARR-seq mESC enhancer starr_37119 Neighboring gene predicted gene, 35450

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell morphogenesis involved in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within enucleate erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of mitotic sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within negative regulation of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of myofibroblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein localization to chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of lipid kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in sister chromatid biorientation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within tissue homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
part_of Rb-E2F complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Rb-E2F complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Rb-E2F complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin lock complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin/CDK positive transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
retinoblastoma-associated protein
Names
retinoblastoma 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009029.3NP_033055.2  retinoblastoma-associated protein

    See identical proteins and their annotated locations for NP_033055.2

    Status: VALIDATED

    Source sequence(s)
    AK141028, BC096525
    Consensus CDS
    CCDS27267.1
    UniProtKB/Swiss-Prot
    P13405, Q4VA62
    UniProtKB/TrEMBL
    Q3URY9
    Related
    ENSMUSP00000022701.7, ENSMUST00000022701.7
    Conserved Domains (4) summary
    pfam01857
    Location:639758
    RB_B; Retinoblastoma-associated protein B domain
    pfam01858
    Location:367567
    RB_A; Retinoblastoma-associated protein A domain
    pfam08934
    Location:761917
    Rb_C; Rb C-terminal domain
    pfam11934
    Location:112219
    DUF3452; Domain of unknown function (DUF3452)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    73430298..73563446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158527.1XP_036014420.1  retinoblastoma-associated protein isoform X1

RNA

  1. XR_383150.5 RNA Sequence