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EIF1AX eukaryotic translation initiation factor 1A X-linked [ Homo sapiens (human) ]

Gene ID: 1964, updated on 31-Dec-2019

Summary

Official Symbol
EIF1AXprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 1A X-linkedprovided by HGNC
Primary source
HGNC:HGNC:3250
See related
Ensembl:ENSG00000173674 MIM:300186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1
Summary
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 20.5), endometrium (RPKM 20.0) and 25 other tissues See more
Orthologs

Genomic context

See EIF1AX in Genome Data Viewer
Location:
Xp22.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (20124525..20141838, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20142636..20159966, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene uncharacterized LOC729609 Neighboring gene MAP7 domain containing 2 Neighboring gene microRNA 23c Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9 like Neighboring gene ribosomal protein S6 kinase A3 Neighboring gene RN7SK pseudogene 183

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 1A, X-chromosomal
Names
Putative eukaryotic translation initiation factor 1A
eIF-1A X isoform
eukaryotic translation initiation factor 1A, X chromosome
eukaryotic translation initiation factor 4C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412.4NP_001403.1  eukaryotic translation initiation factor 1A, X-chromosomal

    See identical proteins and their annotated locations for NP_001403.1

    Status: REVIEWED

    Source sequence(s)
    AL732366, L18960
    Consensus CDS
    CCDS14196.1
    UniProtKB/Swiss-Prot
    P47813
    Related
    ENSP00000368927.5, ENST00000379607.10
    Conserved Domains (1) summary
    PTZ00329
    Location:1131
    PTZ00329; eukaryotic translation initiation factor 1A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    20124525..20141838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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