U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rad9a RAD9 checkpoint clamp component A [ Mus musculus (house mouse) ]

Gene ID: 19367, updated on 8-Feb-2024

Summary

Official Symbol
Rad9aprovided by MGI
Official Full Name
RAD9 checkpoint clamp component Aprovided by MGI
Primary source
MGI:MGI:1328356
See related
Ensembl:ENSMUSG00000024824 AllianceGenome:MGI:1328356
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rad9
Summary
Predicted to enable 3'-5' exonuclease activity; SH3 domain binding activity; and enzyme binding activity. Acts upstream of or within mitotic intra-S DNA damage checkpoint signaling and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Located in cytoplasm and nucleus. Is expressed in retina; testis; and thyroid gland. Orthologous to human RAD9A (RAD9 checkpoint clamp component A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 48.0), spleen adult (RPKM 29.8) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rad9a in Genome Data Viewer
Location:
19 A; 19 3.89 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4245195..4251710, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4195196..4201672, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene carnosine synthase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4184956-4185264 Neighboring gene TBC1 domain family, member 10c Neighboring gene STARR-positive B cell enhancer ABC_E11010 Neighboring gene protein phosphatase 1 catalytic subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E4257 Neighboring gene uncharacterized LOC102631992 Neighboring gene predicted gene, 30082 Neighboring gene STARR-positive B cell enhancer ABC_E11667 Neighboring gene predicted gene, 45928 Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E969 Neighboring gene polymerase (DNA-directed), delta 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA 3'-5' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to radiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of checkpoint clamp complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cell cycle checkpoint control protein RAD9A
Names
DNA repair exonuclease rad9 homolog A
RAD9 homolog A
Rad9-like protein
mRAD9
NP_035367.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011237.2NP_035367.1  cell cycle checkpoint control protein RAD9A

    See identical proteins and their annotated locations for NP_035367.1

    Status: PROVISIONAL

    Source sequence(s)
    AC140073
    Consensus CDS
    CCDS29422.1
    UniProtKB/Swiss-Prot
    Q8QZZ3, Q9Z0F6
    Related
    ENSMUSP00000025740.7, ENSMUST00000025740.8
    Conserved Domains (2) summary
    cd00577
    Location:9267
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam04139
    Location:13265
    Rad9; Rad9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4245195..4251710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_879420.4 RNA Sequence