U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rad54l RAD54 like (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 19366, updated on 18-Apr-2024

Summary

Official Symbol
Rad54lprovided by MGI
Official Full Name
RAD54 like (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:894697
See related
Ensembl:ENSMUSG00000028702 AllianceGenome:MGI:894697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAD54
Summary
Predicted to enable ATP-dependent DNA/DNA annealing activity and DNA translocase activity. Acts upstream of or within several processes, including determination of adult lifespan; double-strand break repair via homologous recombination; and response to ionizing radiation. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in alimentary system; brain ventricular layer; metencephalon rest of alar plate marginal layer; renal cortex; and vibrissa. Used to study sclerocornea. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.3), testis adult (RPKM 10.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
4 D1; 4 53.1 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115951458..115980875, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116094261..116123700, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12854 Neighboring gene STARR-positive B cell enhancer ABC_E4647 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene leucine rich repeat containing 41 Neighboring gene predicted gene, 52704 Neighboring gene RIKEN cDNA 2510003B16 gene Neighboring gene STARR-positive B cell enhancer ABC_E10248 Neighboring gene STARR-seq mESC enhancer starr_11132 Neighboring gene leucine rich adaptor protein 1 Neighboring gene protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA translocase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within double-strand break repair IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to ionizing radiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA repair and recombination protein RAD54-like
Names
RAD54 homolog
mHR54
mRAD54
NP_001116430.1
NP_001116431.1
NP_001411773.1
NP_001411774.1
NP_001411775.1
NP_001411776.1
NP_001411777.1
NP_033041.3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122958.2NP_001116430.1  DNA repair and recombination protein RAD54-like isoform 1

    See identical proteins and their annotated locations for NP_001116430.1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    Consensus CDS
    CCDS18504.1
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
    Related
    ENSMUSP00000099766.4, ENSMUST00000102705.10
    Conserved Domains (3) summary
    COG0553
    Location:107668
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18067
    Location:153395
    DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
    pfam08658
    Location:76123
    Rad54_N; Rad54 N terminal
  2. NM_001122959.2NP_001116431.1  DNA repair and recombination protein RAD54-like isoform 1

    See identical proteins and their annotated locations for NP_001116431.1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    Consensus CDS
    CCDS18504.1
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
    Conserved Domains (3) summary
    COG0553
    Location:107668
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18067
    Location:153395
    DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
    pfam08658
    Location:76123
    Rad54_N; Rad54 N terminal
  3. NM_001424844.1NP_001411773.1  DNA repair and recombination protein RAD54-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
  4. NM_001424845.1NP_001411774.1  DNA repair and recombination protein RAD54-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
  5. NM_001424846.1NP_001411775.1  DNA repair and recombination protein RAD54-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
  6. NM_001424847.1NP_001411776.1  DNA repair and recombination protein RAD54-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
  7. NM_001424848.1NP_001411777.1  DNA repair and recombination protein RAD54-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
  8. NM_009015.4NP_033041.3  DNA repair and recombination protein RAD54-like isoform 1

    See identical proteins and their annotated locations for NP_033041.3

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105
    Consensus CDS
    CCDS18504.1
    UniProtKB/Swiss-Prot
    P70270, Q8BSR5, Q8C2C4, Q8K3D4
    Related
    ENSMUSP00000099765.4, ENSMUST00000102704.4
    Conserved Domains (3) summary
    COG0553
    Location:107668
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18067
    Location:153395
    DEXHc_RAD54A; DEXH-box helicase domain of RAD54A
    pfam08658
    Location:76123
    Rad54_N; Rad54 N terminal

RNA

  1. NR_188962.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611947, AL627105

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115951458..115980875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)