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Rad1 RAD1 checkpoint DNA exonuclease [ Mus musculus (house mouse) ]

Gene ID: 19355, updated on 31-Jan-2019

Summary

Official Symbol
Rad1provided by MGI
Official Full Name
RAD1 checkpoint DNA exonucleaseprovided by MGI
Primary source
MGI:MGI:1316678
See related
Ensembl:ENSMUSG00000022248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mRAD1
Expression
Ubiquitous expression in bladder adult (RPKM 3.3), liver E14 (RPKM 2.9) and 28 other tissues See more
Orthologs

Genomic context

See Rad1 in Genome Data Viewer
Location:
15; 15 A1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (10486018..10499063)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (10415789..10423446)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene BRX1, biogenesis of ribosomes Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
exodeoxyribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
meiotic recombination checkpoint ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell cycle checkpoint protein RAD1
Names
DNA repair exonuclease rad1 homolog
RAD1 homolog
rad1-like DNA damage checkpoint protein
NP_001276376.1
NP_001276377.1
NP_035362.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289447.1NP_001276376.1  cell cycle checkpoint protein RAD1 isoform 1

    See identical proteins and their annotated locations for NP_001276376.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1)
    Source sequence(s)
    AC102101
    Consensus CDS
    CCDS27379.1
    UniProtKB/Swiss-Prot
    Q9QWZ1
    Conserved Domains (2) summary
    cd00577
    Location:19276
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:17257
    Rad1; Repair protein Rad1/Rec1/Rad17
  2. NM_001289448.1NP_001276377.1  cell cycle checkpoint protein RAD1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC102101, AK168588
    Consensus CDS
    CCDS70618.1
    UniProtKB/Swiss-Prot
    Q9QWZ1
    Related
    ENSMUSP00000098338.3, ENSMUST00000100775.9
    Conserved Domains (2) summary
    cd00577
    Location:19228
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:17222
    Rad1; Repair protein Rad1/Rec1/Rad17
  3. NM_011232.3NP_035362.2  cell cycle checkpoint protein RAD1 isoform 1

    See identical proteins and their annotated locations for NP_035362.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AC102101, AK150466
    Consensus CDS
    CCDS27379.1
    UniProtKB/Swiss-Prot
    Q9QWZ1
    Related
    ENSMUSP00000022856.8, ENSMUST00000022856.14
    Conserved Domains (2) summary
    cd00577
    Location:19276
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:17257
    Rad1; Repair protein Rad1/Rec1/Rad17

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    10486018..10499063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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