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Rab7 RAB7, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19349, updated on 8-Jul-2018
Official Symbol
Rab7provided by MGI
Official Full Name
RAB7, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105068
See related
Ensembl:ENSMUSG00000079477 Vega:OTTMUSG00000024646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab7a
Expression
Ubiquitous expression in bladder adult (RPKM 76.7), kidney adult (RPKM 66.7) and 28 other tissues See more
Orthologs
See Rab7 in Genome Data Viewer
Location:
6 D1; 6 39.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (87999106..88045270, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (87950429..87963684, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5577 Neighboring gene H1 histone family, member X Neighboring gene predicted gene, 34872 Neighboring gene predicted gene, 38855 Neighboring gene ribophorin I Neighboring gene microRNA 6376

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
    RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
    TBC/RABGAPs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102153

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GDP binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity ISO
Inferred from Sequence Orthology
more info
 
Rac GTPase binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retromer complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
bone resorption ISO
Inferred from Sequence Orthology
more info
 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor catabolic process ISO
Inferred from Sequence Orthology
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
phagosome acidification ISO
Inferred from Sequence Orthology
more info
 
phagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of viral process ISO
Inferred from Sequence Orthology
more info
 
protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
 
protein to membrane docking ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
alveolar lamellar body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of lysosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
late endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with late endosome ISO
Inferred from Sequence Orthology
more info
 
late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with retromer complex ISO
Inferred from Sequence Orthology
more info
 
vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293652.1NP_001280581.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK152666, AK158971, BY291181, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109226.1, OTTMUSP00000029565, ENSMUST00000113596.7, OTTMUST00000060593
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  2. NM_001293653.1NP_001280582.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK158971, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109228.1, OTTMUSP00000029562, ENSMUST00000113598.7, OTTMUST00000060590
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  3. NM_001293654.1NP_001280583.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK135659, AK158971, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109227.1, OTTMUSP00000029564, ENSMUST00000113597.7, OTTMUST00000060592
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  4. NM_001293655.1NP_001280584.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK135659, AK139914, AK158971, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000092658.3, OTTMUSP00000029563, ENSMUST00000095048.5, OTTMUST00000060591
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  5. NM_009005.3NP_033031.2  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_033031.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK148117, AK158971, BY291181, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109230.3, OTTMUSP00000029561, ENSMUST00000113600.9, OTTMUST00000060589
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    87999106..88045270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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