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Rab7 RAB7, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19349, updated on 17-Oct-2021

Summary

Official Symbol
Rab7provided by MGI
Official Full Name
RAB7, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105068
See related
Ensembl:ENSMUSG00000079477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab7a
Expression
Ubiquitous expression in bladder adult (RPKM 76.7), kidney adult (RPKM 66.7) and 28 other tissues See more
Orthologs
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Genomic context

See Rab7 in Genome Data Viewer
Location:
6 D1; 6 39.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87976088..88022252, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87999106..88045270, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (87950429..87963684, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5577 Neighboring gene H1.10 linker histone Neighboring gene predicted gene, 34872 Neighboring gene predicted gene, 38855 Neighboring gene ribophorin I Neighboring gene microRNA 6376

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102153

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retromer complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in epidermal growth factor catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect establishment of vesicle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in phagosome acidification ISO
Inferred from Sequence Orthology
more info
 
involved_in phagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of exosomal secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein to membrane docking ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
involved_in viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in alveolar lamellar body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of lysosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-7a
NP_001280581.1
NP_001280582.1
NP_001280583.1
NP_001280584.1
NP_033031.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293652.1NP_001280581.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK152666, AK158971, BY291181, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109226.2, ENSMUST00000113596.8
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  2. NM_001293653.1NP_001280582.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK158971, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109228.2, ENSMUST00000113598.8
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  3. NM_001293654.1NP_001280583.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK135659, AK158971, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109227.2, ENSMUST00000113597.8
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  4. NM_001293655.1NP_001280584.1  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_001280584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK135659, AK139914, AK158971, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000092658.4, ENSMUST00000095048.6
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)
  5. NM_009005.3NP_033031.2  ras-related protein Rab-7a

    See identical proteins and their annotated locations for NP_033031.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK148117, AK158971, BY291181, CD774636
    Consensus CDS
    CCDS39552.1
    UniProtKB/Swiss-Prot
    P51150
    UniProtKB/TrEMBL
    Q4FJQ0
    Related
    ENSMUSP00000109230.4, ENSMUST00000113600.10
    Conserved Domains (1) summary
    cd01862
    Location:9179
    Rab7; Rab GTPase family 7 (Rab7)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87976088..88022252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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