Rab7 RAB7, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab7provided by MGI
Official Full Name: RAB7, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:105068
See related: Ensembl:ENSMUSG00000079477 AllianceGenome:MGI:105068
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rab7a
Summary: Predicted to enable several functions, including guanyl ribonucleotide binding activity; retromer complex binding activity; and small GTPase binding activity. Involved in lipophagy; neurotransmitter receptor transport, postsynaptic endosome to lysosome; and vesicle-mediated transport in synapse. Acts upstream of or within with a positive effect on establishment of vesicle localization. Located in several cellular components, including late endosome membrane; lipid droplet; and phagophore assembly site membrane. Is active in glutamatergic synapse and lysosome. Colocalizes with lysosomal membrane. Is expressed in several structures, including 1-cell stage embryo; cerebral cortex; lung mesenchyme; oocyte; and primitive endoderm. Used to study Charcot-Marie-Tooth disease type 2B. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Ubiquitous expression in bladder adult (RPKM 76.7), kidney adult (RPKM 66.7) and 28 other tissues See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 6 D1; 6 39.13 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (87976088..88022252, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (87999106..88045270, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy.
Title: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy.
Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves Mitophagy in Alzheimer's Disease Models.
Title: Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves Mitophagy in Alzheimer's Disease Models.
Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7.
Title: Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7.
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.
Title: Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.
Role of the Cytosolic Domain of the a3 Subunit of V-ATPase in the Interaction with Rab7 and Secretory Lysosome Trafficking in Osteoclasts.
Title: Role of the Cytosolic Domain of the a3 Subunit of V-ATPase in the Interaction with Rab7 and Secretory Lysosome Trafficking in Osteoclasts.
RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension.
Title: RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension.
Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells.
Title: Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells.
Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.
Title: Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.
Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy.
Title: Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy.
Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism.
Title: Loss of small GTPase Rab7 activation in prion infection negatively affects a feedback loop regulating neuronal cholesterol metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (57)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:225345

RAB7A (e-PCR)
- UniSTS:513634

PMC124275P2 (e-PCR)
- UniSTS:270460

Rab7 (e-PCR), detects polymorphism
- UniSTS:144310

Rab7-ps1 (e-PCR), detects polymorphism
- UniSTS:144311

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables retromer complex binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
contributes_to sterol sensor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in bone resorption	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to plasma membrane protein transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome to ER cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of exosomal secretion	IEA Inferred from Electronic Annotation more info
involved_in phagosome acidification	IEA Inferred from Electronic Annotation more info
involved_in phagosome acidification	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagosome-lysosome fusion	IEA Inferred from Electronic Annotation more info
involved_in phagosome-lysosome fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of exosomal secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral process	IEA Inferred from Electronic Annotation more info
involved_in protein localization to lysosome	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to lysosome	IEA Inferred from Electronic Annotation more info
involved_in protein to membrane docking	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle recycling via endosome	IEA Inferred from Electronic Annotation more info
involved_in viral release from host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in alveolar lamellar body	IEA Inferred from Electronic Annotation more info
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
colocalizes_with lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in melanosome membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic endosome	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of retromer complex	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: ras-related protein Rab-7a

NP_001280581.1

EC 3.6.5.2

NP_001280582.1

EC 3.6.5.2

NP_001280583.1

EC 3.6.5.2

NP_001280584.1

EC 3.6.5.2

NP_033031.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293652.1 → NP_001280581.1 ras-related protein Rab-7a

See identical proteins and their annotated locations for NP_001280581.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AK152666, AK158971, BY291181, CD774636

Consensus CDS

CCDS39552.1

UniProtKB/Swiss-Prot

P51150

UniProtKB/TrEMBL

Q4FJQ0

Related

ENSMUSP00000109226.2, ENSMUST00000113596.8

Conserved Domains (1) summary

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)
NM_001293653.1 → NP_001280582.1 ras-related protein Rab-7a

See identical proteins and their annotated locations for NP_001280582.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AK158971, CD774636

Consensus CDS

CCDS39552.1

UniProtKB/Swiss-Prot

P51150

UniProtKB/TrEMBL

Q4FJQ0

Related

ENSMUSP00000109228.2, ENSMUST00000113598.8

Conserved Domains (1) summary

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)
NM_001293654.1 → NP_001280583.1 ras-related protein Rab-7a

See identical proteins and their annotated locations for NP_001280583.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AK135659, AK158971, CD774636

Consensus CDS

CCDS39552.1

UniProtKB/Swiss-Prot

P51150

UniProtKB/TrEMBL

Q4FJQ0

Related

ENSMUSP00000109227.2, ENSMUST00000113597.8

Conserved Domains (1) summary

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)
NM_001293655.1 → NP_001280584.1 ras-related protein Rab-7a

See identical proteins and their annotated locations for NP_001280584.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AK135659, AK139914, AK158971, CD774636

Consensus CDS

CCDS39552.1

UniProtKB/Swiss-Prot

P51150

UniProtKB/TrEMBL

Q4FJQ0

Related

ENSMUSP00000092658.4, ENSMUST00000095048.6

Conserved Domains (1) summary

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)
NM_009005.3 → NP_033031.2 ras-related protein Rab-7a

See identical proteins and their annotated locations for NP_033031.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.

Source sequence(s)

AK148117, AK158971, BY291181, CD774636

Consensus CDS

CCDS39552.1

UniProtKB/Swiss-Prot

P51150

UniProtKB/TrEMBL

Q4FJQ0

Related

ENSMUSP00000109230.4, ENSMUST00000113600.10

Conserved Domains (1) summary

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)