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Rab5b RAB5B, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19344, updated on 26-Sep-2022

Summary

Official Symbol
Rab5bprovided by MGI
Official Full Name
RAB5B, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105938
See related
Ensembl:ENSMUSG00000000711 AllianceGenome:MGI:105938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C030027M18Rik
Summary
Predicted to enable GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Acts upstream of or within endosome organization and regulation of endocytosis. Located in endocytic vesicle. Is expressed in central nervous system and retina. Orthologous to human RAB5B (RAB5B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 40.7), kidney adult (RPKM 39.7) and 28 other tissues See more
Orthologs
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Genomic context

See Rab5b in Genome Data Viewer
Location:
10; 10 D3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128511980..128532160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128677170..128696284, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene IKAROS family zinc finger 4 Neighboring gene predicted gene, 51824 Neighboring gene sulfite oxidase Neighboring gene ribosomal protein L12 pseudogene Neighboring gene premelanosome protein Neighboring gene cyclin-dependent kinase 2 Neighboring gene diacylglycerol kinase, alpha Neighboring gene predicted gene, 31504 Neighboring gene PYM homolog 1, exon junction complex associated factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC169198, MGC169199

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endosome organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in plasma membrane to endosome transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-5B
NP_803130.1
XP_006513447.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177411.4NP_803130.1  ras-related protein Rab-5B

    See identical proteins and their annotated locations for NP_803130.1

    Status: VALIDATED

    Source sequence(s)
    AC117232, AK081251, BY727964
    Consensus CDS
    CCDS24287.1
    UniProtKB/Swiss-Prot
    P35277, P61021
    UniProtKB/TrEMBL
    A0A6P5QND5, A0A8C6MP01, B2RPS1
    Related
    ENSMUSP00000000727.3, ENSMUST00000000727.4
    Conserved Domains (1) summary
    cd01860
    Location:20182
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128511980..128532160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513384.5XP_006513447.1  ras-related protein Rab-5B isoform X1

    See identical proteins and their annotated locations for XP_006513447.1

    UniProtKB/Swiss-Prot
    P35277, P61021
    UniProtKB/TrEMBL
    A0A6P5QND5, A0A8C6MP01, B2RPS1
    Conserved Domains (1) summary
    cd01860
    Location:20182
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011229.1: Suppressed sequence

    Description
    NM_011229.1: This RefSeq was permanently suppressed because it is redundant with NM_177411.3.