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Itgb4 integrin beta 4 [ Mus musculus (house mouse) ]

Gene ID: 192897, updated on 16-Apr-2019

Summary

Official Symbol
Itgb4provided by MGI
Official Full Name
integrin beta 4provided by MGI
Primary source
MGI:MGI:96613
See related
Ensembl:ENSMUSG00000020758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD104; AA407042; C230078O20
Summary
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon adult (RPKM 42.1), small intestine adult (RPKM 34.8) and 13 other tissues See more
Orthologs

Genomic context

See Itgb4 in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
41
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (115974725..116008412)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115836039..115869725)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 6 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene galactokinase 1 Neighboring gene H3 histone, family 3B Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to neuregulin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
amelogenesis ISO
Inferred from Sequence Orthology
more info
 
autophagy ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell communication IEA
Inferred from Electronic Annotation
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell motility ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
digestive tract development ISO
Inferred from Sequence Orthology
more info
 
filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemidesmosome assembly ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myelination in peripheral nervous system IGI
Inferred from Genetic Interaction
more info
PubMed 
nail development ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system myelin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
renal system development ISO
Inferred from Sequence Orthology
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
skin development ISO
Inferred from Sequence Orthology
more info
 
trophoblast cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemidesmosome IDA
Inferred from Direct Assay
more info
PubMed 
hemidesmosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005608.2NP_001005608.2  integrin beta-4 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA407046, AK048888, AK147424, BE863493
    Consensus CDS
    CCDS36376.1
    UniProtKB/TrEMBL
    A2A864
    Related
    ENSMUSP00000127604.1, ENSMUST00000169928.7
    Conserved Domains (6) summary
    smart00237
    Location:9911085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:12181311
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:16221707
    fn3; Fibronectin type III domain
    pfam00362
    Location:38455
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:628710
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
  2. NM_133663.2NP_598424.2  integrin beta-4 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site and lacks an alternate in-frame exon in the 3' coding region, as compared to variant 1. The resulting protein (isoform 2) thus has two differences with a shorter C-terminus when compared to isoform 1.
    Source sequence(s)
    AA407046, AK048888, AK147424
    Conserved Domains (6) summary
    smart00237
    Location:9911085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:12211314
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:15721657
    fn3; Fibronectin type III domain
    pfam00362
    Location:38455
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:628710
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:547575
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    115974725..116008412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532574.2XP_006532637.1  integrin beta-4 isoform X6

    UniProtKB/Swiss-Prot
    A2A863
    Related
    ENSMUSP00000070811.6, ENSMUST00000068981.12
    Conserved Domains (6) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:12221315
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:15731658
    fn3; Fibronectin type III domain
    pfam00362
    Location:38455
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:628711
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:547575
    EGF_2; EGF-like domain
  2. XM_017314349.1XP_017169838.1  integrin beta-4 isoform X1

  3. XM_006532572.3XP_006532635.1  integrin beta-4 isoform X4

    See identical proteins and their annotated locations for XP_006532635.1

    UniProtKB/Swiss-Prot
    A2A863
    Related
    ENSMUSP00000102069.1, ENSMUST00000106461.7
    Conserved Domains (6) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:12221315
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:16381723
    fn3; Fibronectin type III domain
    pfam00362
    Location:38455
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:628711
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
  4. XM_006532573.3XP_006532636.1  integrin beta-4 isoform X5

    UniProtKB/Swiss-Prot
    A2A863
    Related
    ENSMUSP00000102068.2, ENSMUST00000106460.8
    Conserved Domains (6) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:12221315
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:16261711
    fn3; Fibronectin type III domain
    pfam00362
    Location:38455
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:628711
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
  5. XM_017314351.1XP_017169840.1  integrin beta-4 isoform X3

  6. XM_017314350.1XP_017169839.1  integrin beta-4 isoform X2

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