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Itgb4 integrin beta 4 [ Mus musculus (house mouse) ]

Gene ID: 192897, updated on 9-Dec-2024

Summary

Official Symbol
Itgb4provided by MGI
Official Full Name
integrin beta 4provided by MGI
Primary source
MGI:MGI:96613
See related
Ensembl:ENSMUSG00000020758 AllianceGenome:MGI:96613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD104; C230078O20
Summary
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon adult (RPKM 42.1), small intestine adult (RPKM 34.8) and 13 other tissues See more
Orthologs
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Genomic context

See Itgb4 in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115865556..115899238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115974725..116008412)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E1850 Neighboring gene STARR-seq mESC enhancer starr_31180 Neighboring gene STARR-seq mESC enhancer starr_31181 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene STARR-seq mESC enhancer starr_31187 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene galactokinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene predicted gene, 38482 Neighboring gene unkempt family zinc finger

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to insulin-like growth factor I binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to neuregulin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to neuregulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in hemidesmosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in mesodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myelination in peripheral nervous system IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nail development IEA
Inferred from Electronic Annotation
more info
 
involved_in nail development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peripheral nervous system myelin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in skin morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in skin morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within trophoblast cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in hemidesmosome ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005608.3NP_001005608.2  integrin beta-4 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL645647
    Consensus CDS
    CCDS36376.1
    UniProtKB/TrEMBL
    A2A864
    Related
    ENSMUSP00000127604.2, ENSMUST00000169928.8
    Conserved Domains (7) summary
    smart00237
    Location:9911085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:15081589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
    pfam00041
    Location:16221707
    fn3; Fibronectin type III domain
    pfam07965
    Location:628710
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_001405126.1NP_001392055.1  integrin beta-4 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL645647
    Related
    ENSMUSP00000070811.7, ENSMUST00000068981.13
  3. NM_001405127.1NP_001392056.1  integrin beta-4 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL645647
  4. NM_133663.3NP_598424.2  integrin beta-4 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL607108, AL645647
    Conserved Domains (7) summary
    smart00237
    Location:9911085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:14581539
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07974
    Location:547575
    EGF_2; EGF-like domain
    pfam00041
    Location:15721657
    fn3; Fibronectin type III domain
    pfam07965
    Location:628710
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115865556..115899238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156446.1XP_036012339.1  integrin beta-4 isoform X8

    Conserved Domains (6) summary
    smart00237
    Location:9911085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:14551536
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:15691654
    fn3; Fibronectin type III domain
    pfam07965
    Location:628710
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. XM_017314349.3XP_017169838.1  integrin beta-4 isoform X1

    Conserved Domains (7) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:15771658
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
    pfam00041
    Location:16911776
    fn3; Fibronectin type III domain
    pfam07965
    Location:628711
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. XM_006532572.5XP_006532635.1  integrin beta-4 isoform X4

    See identical proteins and their annotated locations for XP_006532635.1

    UniProtKB/Swiss-Prot
    A2A863, A2A865, A2A866, Q6PCS0, Q8R3J1, Q91W15
    Related
    ENSMUSP00000102069.2, ENSMUST00000106461.8
    Conserved Domains (7) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:15241605
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
    pfam00041
    Location:16381723
    fn3; Fibronectin type III domain
    pfam07965
    Location:628711
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  4. XM_006532573.5XP_006532636.1  integrin beta-4 isoform X5

    UniProtKB/Swiss-Prot
    A2A863
    Related
    ENSMUSP00000102068.3, ENSMUST00000106460.9
    Conserved Domains (7) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:15121593
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
    pfam00041
    Location:16261711
    fn3; Fibronectin type III domain
    pfam07965
    Location:628711
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  5. XM_017314351.3XP_017169840.1  integrin beta-4 isoform X3

    Conserved Domains (7) summary
    smart00237
    Location:9921086
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:15741655
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
    pfam00041
    Location:16881773
    fn3; Fibronectin type III domain
    pfam07965
    Location:628711
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  6. XM_017314350.3XP_017169839.1  integrin beta-4 isoform X2

    Conserved Domains (7) summary
    smart00237
    Location:9911085
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:15761657
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07974
    Location:545575
    EGF_2; EGF-like domain
    pfam00041
    Location:16901775
    fn3; Fibronectin type III domain
    pfam07965
    Location:628710
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:459487
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
    cl00057
    Location:38455
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  7. XM_036156447.1XP_036012340.1  integrin beta-4 isoform X9

    UniProtKB/TrEMBL
    Q3UNP2
    Conserved Domains (3) summary
    smart00237
    Location:94188
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    cd00063
    Location:679760
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:793878
    fn3; Fibronectin type III domain