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Ptpru protein tyrosine phosphatase receptor type U [ Mus musculus (house mouse) ]

Gene ID: 19273, updated on 2-Nov-2024

Summary

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Official Symbol
Ptpruprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Uprovided by MGI
Primary source
MGI:MGI:1321151
See related
Ensembl:ENSMUSG00000028909 AllianceGenome:MGI:1321151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTP; Pcp2; Ptpf; Ftp-1; PCP-2; Ptprl; R-PTP-U; PTPlambda; R-PTP-psi; PTP-lambda; RPTPlambda
Summary
Enables beta-catenin binding activity. Acts upstream of or within homotypic cell-cell adhesion. Predicted to be located in cell-cell junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PTPRU (protein tyrosine phosphatase receptor type U). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 20.7), bladder adult (RPKM 17.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Ptpru in Genome Data Viewer
Location:
4 D2.3; 4 64.5 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131495768..131565617, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131768457..131838306, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568696 Neighboring gene STARR-seq mESC enhancer starr_11548 Neighboring gene predicted gene, 42321 Neighboring gene predicted gene, 52680 Neighboring gene STARR-positive B cell enhancer ABC_E10262 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine-rich splicing factor 4 Neighboring gene predicted gene 12992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic structure and alternative splicing of murine R2B receptor protein tyrosine phosphatases (PTPkappa, mu, rho and PCP-2). Besco J, et al. BMC Genomics, 2004 Feb 11. PMID 15040814, Free PMC Article
  2. Molecular cloning of a novel receptor-type protein tyrosine phosphatase from murine fetal liver. Yoneya T, et al. Gene, 1997 Jul 31. PMID 9272866
  3. A novel protein-tyrosine phosphatase related to the homotypically adhering kappa and mu receptors. Cheng J, et al. J Biol Chem, 1997 Mar 14. PMID 9054423
  4. Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development. Fuchs M, et al. Mech Dev, 1998 Jan. PMID 9510027
  5. Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. Avraham S, et al. Gene, 1997 Dec 19. PMID 9434160

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase U
Names
Pancreatic carcinoma phosphatase 2
Protein-tyrosine phosphatase-lamda
Receptor-type protein-tyrosine phosphatase psi
protein tyrosine phosphatase, receptor type, L
NP_001076588.1
NP_035344.2
XP_006538729.1
XP_006538730.1
XP_006538731.1
XP_006538733.1
XP_006538735.1
XP_006538736.1
XP_006538737.1
XP_011248512.1
XP_011248513.1
XP_011248514.1
XP_011248515.1
XP_011248516.1
XP_011248517.1
XP_036019791.1
XP_036019793.1
XP_036019794.1
XP_036019795.1
XP_036019796.1
XP_036019797.1
XP_036019798.1
XP_036019799.1
XP_036019800.1
XP_036019801.1
XP_036019802.1
XP_036019803.1
XP_036019804.1
XP_036019805.1
XP_036019806.1
XP_036019807.1
XP_036019808.1
XP_036019809.1
XP_036019810.1
XP_036019811.1
XP_036019812.1
XP_036019813.1
XP_036019814.1
XP_036019815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083119.3 → NP_001076588.1  receptor-type tyrosine-protein phosphatase U isoform 2 precursor

    See identical proteins and their annotated locations for NP_001076588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AL670959
    Consensus CDS
    CCDS38896.1
    UniProtKB/Swiss-Prot
    B1AUH1, O35564, P70125, Q3V312, Q66JV9
    Related
    ENSMUSP00000030741.3, ENSMUST00000030741.9
    Conserved Domains (8) summary
    cd06263
    Location:27 → 186
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:1175 → 1438
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:196 → 282
    IG_like; Immunoglobulin like
    cd00047
    Location:922 → 1143
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:484 → 585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:291 → 366
    fn3; Fibronectin type III domain
    pfam00102
    Location:918 → 1143
    Y_phosphatase; Protein-tyrosine phosphatase

  2. NM_011214.3 → NP_035344.2  receptor-type tyrosine-protein phosphatase U isoform 1 precursor

    See identical proteins and their annotated locations for NP_035344.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 1, which is shorter than isoform 2.
    Source sequence(s)
    AL670959
    Consensus CDS
    CCDS18714.1
    UniProtKB/Swiss-Prot
    B1AUH1
    UniProtKB/TrEMBL
    Q80ZN2
    Related
    ENSMUSP00000101607.3, ENSMUST00000105987.9
    Conserved Domains (8) summary
    cd06263
    Location:27 → 186
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:1165 → 1428
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:196 → 282
    IG_like; Immunoglobulin like
    cd00047
    Location:912 → 1133
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:484 → 585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:291 → 366
    fn3; Fibronectin type III domain
    pfam00102
    Location:908 → 1133
    Y_phosphatase; Protein-tyrosine phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131495768..131565617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250210.4 → XP_011248512.1  receptor-type tyrosine-protein phosphatase U isoform X1

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:204 → 290
    IG; Immunoglobulin
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1259 → 1465
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain
    cl28904
    Location:951 → 1174
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_036163920.1 → XP_036019813.1  receptor-type tyrosine-protein phosphatase U isoform X30

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:608 → 812
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:897 → 1103
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain

  3. XM_036163915.1 → XP_036019808.1  receptor-type tyrosine-protein phosphatase U isoform X27

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:916 → 1122
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain
    cl28904
    Location:608 → 831
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_036163909.1 → XP_036019802.1  receptor-type tyrosine-protein phosphatase U isoform X24

    Conserved Domains (6) summary
    smart00410
    Location:44 → 130
    IG_like; Immunoglobulin like
    cd00063
    Location:234 → 329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:781 → 985
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1070 → 1276
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:342 → 425
    fn3; Fibronectin type III domain
    cl27660
    Location:7 → 34
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

  5. XM_036163918.1 → XP_036019811.1  receptor-type tyrosine-protein phosphatase U isoform X30

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:608 → 812
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:897 → 1103
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain

  6. XM_036163914.1 → XP_036019807.1  receptor-type tyrosine-protein phosphatase U isoform X27

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:916 → 1122
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain
    cl28904
    Location:608 → 831
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  7. XM_036163917.1 → XP_036019810.1  receptor-type tyrosine-protein phosphatase U isoform X29

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:904 → 1110
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain
    cl28904
    Location:618 → 819
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  8. XM_036163912.1 → XP_036019805.1  receptor-type tyrosine-protein phosphatase U isoform X26

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:926 → 1132
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain
    cl28904
    Location:618 → 841
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  9. XM_036163901.1 → XP_036019794.1  receptor-type tyrosine-protein phosphatase U isoform X13

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:196 → 282
    IG; Immunoglobulin
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1232 → 1438
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain
    cl28904
    Location:933 → 1147
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  10. XM_036163900.1 → XP_036019793.1  receptor-type tyrosine-protein phosphatase U isoform X12

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:196 → 282
    IG; Immunoglobulin
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1235 → 1441
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain
    cl28904
    Location:933 → 1150
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  11. XM_006538673.4 → XP_006538736.1  receptor-type tyrosine-protein phosphatase U isoform X16

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:196 → 282
    IG_like; Immunoglobulin like
    cd00063
    Location:484 → 585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1228 → 1434
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:291 → 365
    fn3; Fibronectin type III domain
    cl28904
    Location:933 → 1143
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  12. XM_011250215.4 → XP_011248517.1  receptor-type tyrosine-protein phosphatase U isoform X9

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:196 → 282
    IG; Immunoglobulin
    cd00063
    Location:484 → 585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1241 → 1447
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:291 → 365
    fn3; Fibronectin type III domain
    cl28904
    Location:933 → 1156
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  13. XM_036163902.1 → XP_036019795.1  receptor-type tyrosine-protein phosphatase U isoform X15

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:196 → 282
    IG; Immunoglobulin
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1229 → 1435
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain
    cl28904
    Location:943 → 1144
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  14. XM_011250213.4 → XP_011248515.1  receptor-type tyrosine-protein phosphatase U isoform X4

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:196 → 282
    IG_like; Immunoglobulin like
    cd00063
    Location:484 → 585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1251 → 1457
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:291 → 365
    fn3; Fibronectin type III domain
    cl28904
    Location:943 → 1166
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  15. XM_006538674.4 → XP_006538737.1  receptor-type tyrosine-protein phosphatase U isoform X18

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:196 → 282
    IG; Immunoglobulin
    cd00063
    Location:484 → 585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1219 → 1425
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:291 → 365
    fn3; Fibronectin type III domain
    cl28904
    Location:933 → 1134
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  16. XM_036163898.1 → XP_036019791.1  receptor-type tyrosine-protein phosphatase U isoform X7

    Conserved Domains (6) summary
    smart00137
    Location:22 → 186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:196 → 282
    IG; Immunoglobulin
    cd00063
    Location:386 → 481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1245 → 1451
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494 → 577
    fn3; Fibronectin type III domain
    cl28904
    Location:943 → 1160
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  17. XM_036163911.1 → XP_036019804.1  receptor-type tyrosine-protein phosphatase U isoform X25

    Conserved Domains (6) summary
    smart00410
    Location:44 → 130
    IG_like; Immunoglobulin like
    cd00063
    Location:234 → 329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1067 → 1273
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:342 → 425
    fn3; Fibronectin type III domain
    cl27660
    Location:7 → 34
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    cl28904
    Location:781 → 982
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  18. XM_036163908.1 → XP_036019801.1  receptor-type tyrosine-protein phosphatase U isoform X23

    Conserved Domains (6) summary
    smart00409
    Location:44 → 130
    IG; Immunoglobulin
    cd00063
    Location:234 → 329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1077 → 1283
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:342 → 425
    fn3; Fibronectin type III domain
    cl27660
    Location:7 → 34
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    cl28904
    Location:791 → 992
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  19. XM_036163907.1 → XP_036019800.1  receptor-type tyrosine-protein phosphatase U isoform X22

    Conserved Domains (6) summary
    smart00410
    Location:44 → 130
    IG_like; Immunoglobulin like
    cd00063
    Location:234 → 329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:791 → 995
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1080 → 1286
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:342 → 425
    fn3; Fibronectin type III domain
    cl27660
    Location:7 → 34
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

  20. XM_036163921.1 → XP_036019814.1  receptor-type tyrosine-protein phosphatase U isoform X31

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:894 → 1100
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain
    cl28904
    Location:608 → 809
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  21. XM_036163916.1 → XP_036019809.1  receptor-type tyrosine-protein phosphatase U isoform X28

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:618 → 822
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:907 → 1113
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain

  22. XM_036163905.1 → XP_036019798.1  receptor-type tyrosine-protein phosphatase U isoform X20

    Conserved Domains (6) summary
    smart00137
    Location:1 → 114
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:124 → 210
    IG; Immunoglobulin
    cd00063
    Location:314 → 409
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:861 → 1065
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1150 → 1356
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:422 → 505
    fn3; Fibronectin type III domain

  23. XM_036163904.1 → XP_036019797.1  receptor-type tyrosine-protein phosphatase U isoform X19

    Conserved Domains (6) summary
    smart00137
    Location:1 → 114
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:124 → 210
    IG_like; Immunoglobulin like
    cd00063
    Location:314 → 409
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:871 → 1075
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1160 → 1366
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:422 → 505
    fn3; Fibronectin type III domain

  24. XM_036163906.1 → XP_036019799.1  receptor-type tyrosine-protein phosphatase U isoform X21

    Conserved Domains (6) summary
    smart00137
    Location:1 → 114
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:124 → 210
    IG_like; Immunoglobulin like
    cd00063
    Location:314 → 409
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1147 → 1353
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:422 → 505
    fn3; Fibronectin type III domain
    cl28904
    Location:861 → 1062
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  25. XM_036163910.1 → XP_036019803.1  receptor-type tyrosine-protein phosphatase U isoform X24

    Conserved Domains (6) summary
    smart00410
    Location:44 → 130
    IG_like; Immunoglobulin like
    cd00063
    Location:234 → 329
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:781 → 985
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1070 → 1276
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:342 → 425
    fn3; Fibronectin type III domain
    cl27660
    Location:7 → 34
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

  26. XM_036163919.1 → XP_036019812.1  receptor-type tyrosine-protein phosphatase U isoform X30

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:608 → 812
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:897 → 1103
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain

  27. XM_036163913.1 → XP_036019806.1  receptor-type tyrosine-protein phosphatase U isoform X26

    Conserved Domains (4) summary
    cd00063
    Location:61 → 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:926 → 1132
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:169 → 252
    fn3; Fibronectin type III domain
    cl28904
    Location:618 → 841
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  28. XM_011250211.4 → XP_011248513.1  receptor-type tyrosine-protein phosphatase U isoform X2

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:204 → 290
    IG; Immunoglobulin
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1256 → 1462
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain
    cl28904
    Location:951 → 1171
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  29. XM_006538667.5 → XP_006538730.1  receptor-type tyrosine-protein phosphatase U isoform X8

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:204 → 290
    IG_like; Immunoglobulin like
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1243 → 1449
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain
    cl28904
    Location:951 → 1158
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  30. XM_011250214.4 → XP_011248516.1  receptor-type tyrosine-protein phosphatase U isoform X5

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:204 → 290
    IG_like; Immunoglobulin like
    cd00063
    Location:492 → 593
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1249 → 1455
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:299 → 373
    fn3; Fibronectin type III domain
    cl28904
    Location:941 → 1164
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  31. XM_011250212.4 → XP_011248514.1  receptor-type tyrosine-protein phosphatase U isoform X3

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:204 → 290
    IG; Immunoglobulin
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1253 → 1459
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain
    cl28904
    Location:951 → 1168
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  32. XM_006538670.5 → XP_006538733.1  receptor-type tyrosine-protein phosphatase U isoform X11

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:204 → 290
    IG; Immunoglobulin
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1237 → 1443
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain
    cl28904
    Location:951 → 1152
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  33. XM_006538666.5 → XP_006538729.1  receptor-type tyrosine-protein phosphatase U isoform X6

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:204 → 290
    IG_like; Immunoglobulin like
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1246 → 1452
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain
    cl28904
    Location:951 → 1161
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  34. XM_036163903.1 → XP_036019796.1  receptor-type tyrosine-protein phosphatase U isoform X17

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:204 → 290
    IG; Immunoglobulin
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:1227 → 1433
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain
    cl28904
    Location:941 → 1142
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  35. XM_006538668.5 → XP_006538731.1  receptor-type tyrosine-protein phosphatase U isoform X10

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:204 → 290
    IG; Immunoglobulin
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:951 → 1155
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1240 → 1446
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain

  36. XM_006538672.5 → XP_006538735.1  receptor-type tyrosine-protein phosphatase U isoform X14

    Conserved Domains (6) summary
    smart00137
    Location:31 → 194
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00409
    Location:204 → 290
    IG; Immunoglobulin
    cd00063
    Location:394 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14632
    Location:941 → 1145
    R-PTPc-U-1; catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1
    cd14637
    Location:1230 → 1436
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:502 → 585
    fn3; Fibronectin type III domain

  37. XM_036163922.1 → XP_036019815.1  receptor-type tyrosine-protein phosphatase U isoform X32

    Conserved Domains (3) summary
    cd14637
    Location:811 → 1017
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:54 → 137
    fn3; Fibronectin type III domain
    cl28904
    Location:503 → 726
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AUH1.1 GenPept UniProtKB/Swiss-Prot:B1AUH1

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