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Ell2 elongation factor for RNA polymerase II 2 [ Mus musculus (house mouse) ]

Gene ID: 192657, updated on 8-Feb-2024

Summary

Official Symbol
Ell2provided by MGI
Official Full Name
elongation factor for RNA polymerase II 2provided by MGI
Primary source
MGI:MGI:2183438
See related
Ensembl:ENSMUSG00000001542 AllianceGenome:MGI:2183438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in snRNA transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription elongation from RNA polymerase II promoter and transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including branchial arch; eye; inner ear; limb ectoderm; and maxillary process. Orthologous to human ELL2 (elongation factor for RNA polymerase II 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 25.8), liver E14.5 (RPKM 21.9) and 24 other tissues See more
Orthologs
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Genomic context

See Ell2 in Genome Data Viewer
Location:
13 C1; 13 40.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (75855603..75920480)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (75707484..75772361)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700037F03 gene Neighboring gene microRNA 682 Neighboring gene ribosomal protein L37a pseudogene Neighboring gene STARR-seq mESC enhancer starr_35042 Neighboring gene STARR-seq mESC enhancer starr_35043 Neighboring gene STARR-positive B cell enhancer ABC_E7253 Neighboring gene predicted gene, 23012 Neighboring gene STARR-positive B cell enhancer ABC_E603 Neighboring gene STARR-seq mESC enhancer starr_35045 Neighboring gene predicted gene, 23127 Neighboring gene STARR-seq mESC enhancer starr_35046 Neighboring gene STARR-seq mESC enhancer starr_35047 Neighboring gene STARR-seq mESC enhancer starr_35048 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:75935293-75935499 Neighboring gene STARR-positive B cell enhancer ABC_E4080 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 41005 Neighboring gene STARR-seq mESC enhancer starr_35051 Neighboring gene glutaredoxin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General protein information

Preferred Names
RNA polymerase II elongation factor ELL2
Names
ELL-related RNA polymerase II, elongation factor
eleven-nineteen lysine-rich leukemia gene 2
elongation factor RNA polymerase II 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138953.2NP_620403.2  RNA polymerase II elongation factor ELL2

    See identical proteins and their annotated locations for NP_620403.2

    Status: VALIDATED

    Source sequence(s)
    AK145868, BE133837, CT025556
    Consensus CDS
    CCDS36734.1
    UniProtKB/Swiss-Prot
    E9QPE1, Q3UKU1
    UniProtKB/TrEMBL
    B9EKX8
    Related
    ENSMUSP00000001583.7, ENSMUST00000001583.8
    Conserved Domains (2) summary
    pfam07303
    Location:534631
    Occludin_ELL; Occludin homology domain
    pfam10390
    Location:11289
    ELL; RNA polymerase II elongation factor ELL

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    75855603..75920480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)