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Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [ Mus musculus (house mouse) ]

Gene ID: 19260, updated on 13-Feb-2024

Summary

Official Symbol
Ptpn22provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)provided by MGI
Primary source
MGI:MGI:107170
See related
Ensembl:ENSMUSG00000027843 AllianceGenome:MGI:107170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEP; Ptpn8; 70zpep
Summary
Enables SH3 domain binding activity and kinase binding activity. Involved in several processes, including regulation of T cell activation; regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within T cell differentiation; T cell receptor signaling pathway; and protein dephosphorylation. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); chronic lymphocytic leukemia; and pulmonary tuberculosis. Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.9), thymus adult (RPKM 4.1) and 10 other tissues See more
Orthologs
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Genomic context

See Ptpn22 in Genome Data Viewer
Location:
3 F2.2; 3 45.52 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103763891..103819568)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103856575..103912252)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11207 Neighboring gene DNA cross-link repair 1B Neighboring gene adaptor-related protein complex AP-4, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E7934 Neighboring gene STARR-seq mESC enhancer starr_08603 Neighboring gene BCLl2-like 15 Neighboring gene STARR-positive B cell enhancer ABC_E3458 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103663204-103663387 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:103664081-103664275 Neighboring gene STARR-positive B cell enhancer ABC_E6094 Neighboring gene STARR-positive B cell enhancer ABC_E2090 Neighboring gene STARR-seq mESC enhancer starr_08604 Neighboring gene STARR-positive B cell enhancer ABC_E9222 Neighboring gene STARR-positive B cell enhancer mm9_chr3:103718150-103718451 Neighboring gene rosbin, round spermatid basic protein 1 Neighboring gene putative homeodomain transcription factor 1, opposite strand Neighboring gene putative homeodomain transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_08605

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphoanandamide dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of CD8-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granzyme B production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in regulation of antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 22
Names
PEST domain-enriched tyrosine phosphatase
hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
protein tyrosine phosphatase, non-receptor type 8
NP_001396723.1
NP_001396724.1
NP_033005.1
XP_006501211.1
XP_006501212.1
XP_006501213.1
XP_011238343.1
XP_011238344.1
XP_017174993.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409794.1NP_001396723.1  tyrosine-protein phosphatase non-receptor type 22 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124698
    UniProtKB/Swiss-Prot
    P29352, Q7TMP9
    UniProtKB/TrEMBL
    E9QAS3
  2. NM_001409795.1NP_001396724.1  tyrosine-protein phosphatase non-receptor type 22 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124698
    UniProtKB/TrEMBL
    E9QAS3
  3. NM_008979.3NP_033005.1  tyrosine-protein phosphatase non-receptor type 22 isoform 1

    See identical proteins and their annotated locations for NP_033005.1

    Status: VALIDATED

    Source sequence(s)
    AC124698
    Consensus CDS
    CCDS38577.1
    UniProtKB/Swiss-Prot
    P29352, Q7TMP9
    UniProtKB/TrEMBL
    E9QAS3
    Related
    ENSMUSP00000029433.8, ENSMUST00000029433.9
    Conserved Domains (1) summary
    cd14602
    Location:57290
    PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22

RNA

  1. NR_104070.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124698
    Related
    ENSMUST00000146071.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    103763891..103819568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501148.4XP_006501211.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

    See identical proteins and their annotated locations for XP_006501211.1

    UniProtKB/Swiss-Prot
    P29352, Q7TMP9
    UniProtKB/TrEMBL
    E9QAS3
    Conserved Domains (1) summary
    cd14602
    Location:57290
    PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
  2. XM_006501149.4XP_006501212.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

    See identical proteins and their annotated locations for XP_006501212.1

    UniProtKB/Swiss-Prot
    P29352, Q7TMP9
    UniProtKB/TrEMBL
    E9QAS3
    Conserved Domains (1) summary
    cd14602
    Location:57290
    PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
  3. XM_006501150.3XP_006501213.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

    See identical proteins and their annotated locations for XP_006501213.1

    UniProtKB/Swiss-Prot
    P29352, Q7TMP9
    UniProtKB/TrEMBL
    E9QAS3
    Conserved Domains (1) summary
    cd14602
    Location:57290
    PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
  4. XM_011240041.3XP_011238343.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

    See identical proteins and their annotated locations for XP_011238343.1

    UniProtKB/Swiss-Prot
    P29352, Q7TMP9
    UniProtKB/TrEMBL
    E9QAS3
    Conserved Domains (1) summary
    cd14602
    Location:57290
    PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
  5. XM_011240042.3XP_011238344.1  tyrosine-protein phosphatase non-receptor type 22 isoform X1

    See identical proteins and their annotated locations for XP_011238344.1

    UniProtKB/Swiss-Prot
    P29352, Q7TMP9
    UniProtKB/TrEMBL
    E9QAS3
    Conserved Domains (1) summary
    cd14602
    Location:57290
    PTPc-N22; catalytic domain of tyrosine-protein phosphatase non-receptor type 22
  6. XM_017319504.3XP_017174993.1  tyrosine-protein phosphatase non-receptor type 22 isoform X2

    UniProtKB/TrEMBL
    E9QAS3
    Conserved Domains (1) summary
    cl28904
    Location:1175
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily