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Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 [ Mus musculus (house mouse) ]

Gene ID: 19181, updated on 8-Jan-2023

Summary

Official Symbol
Psmc2provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, ATPase 2provided by MGI
Primary source
MGI:MGI:109555
See related
Ensembl:ENSMUSG00000028932 AllianceGenome:MGI:109555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable TBP-class protein binding activity and proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome accessory complex. Is expressed in genitourinary system. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 61.8), CNS E11.5 (RPKM 44.8) and 25 other tissues See more
Orthologs
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Genomic context

See Psmc2 in Genome Data Viewer
Location:
5 A3; 5 9.97 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21990273..22008785)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21785275..21803787)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15715 Neighboring gene peptidase (mitochondrial processing) beta Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene solute carrier family 26, member 5 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene reelin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proteasome-activating activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
26S proteasome regulatory subunit 7
Names
26S protease regulatory subunit 7
26S proteasome AAA-ATPase subunit RPT1
proteasome 26S subunit ATPase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368661.1NP_001355590.1  26S proteasome regulatory subunit 7

    Status: VALIDATED

    Source sequence(s)
    AC125313
    Consensus CDS
    CCDS19108.1
    UniProtKB/Swiss-Prot
    Q9DBA1
    UniProtKB/TrEMBL
    A0A6P5PNH8
    Conserved Domains (1) summary
    COG1222
    Location:23430
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
  2. NM_011188.4NP_035318.2  26S proteasome regulatory subunit 7

    Status: VALIDATED

    Source sequence(s)
    AC125313
    Consensus CDS
    CCDS19108.1
    UniProtKB/Swiss-Prot
    Q9DBA1
    UniProtKB/TrEMBL
    A0A6P5PNH8
    Related
    ENSMUSP00000030769.7, ENSMUST00000030769.7
    Conserved Domains (1) summary
    COG1222
    Location:23430
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21990273..22008785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)