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Psmb1 proteasome (prosome, macropain) subunit, beta type 1 [ Mus musculus (house mouse) ]

Gene ID: 19170, updated on 12-May-2024

Summary

Official Symbol
Psmb1provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 1provided by MGI
Primary source
MGI:MGI:104884
See related
Ensembl:ENSMUSG00000014769 AllianceGenome:MGI:104884
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmpc5
Summary
Predicted to enable peptidase activity. Predicted to be involved in proteasomal protein catabolic process. Part of proteasome core complex. Is expressed in central nervous system; dorsal root ganglion; integumental system; rib; and sensory organ. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 121.4), large intestine adult (RPKM 112.6) and 28 other tissues See more
Orthologs
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Genomic context

See Psmb1 in Genome Data Viewer
Location:
17 A2; 17 8.95 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15695983..15718538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (15475721..15498276, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930024N18 gene Neighboring gene delta like canonical Notch ligand 1 Neighboring gene STARR-positive B cell enhancer ABC_E1931 Neighboring gene family with sequence similarity 120, member B Neighboring gene predicted gene, 49668 Neighboring gene STARR-positive B cell enhancer ABC_E5573 Neighboring gene TATA box binding protein Neighboring gene STARR-positive B cell enhancer ABC_E5574 Neighboring gene programmed cell death 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteasome subunit beta type-1
Names
component C5 of proteasome
macropain subunit C5
multicatalytic endopeptidase complex subunit C5
proteasome beta-subunit C5
proteasome component C5
proteasome gamma chain
proteasome subunit C5
NP_035315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011185.3NP_035315.1  proteasome subunit beta type-1

    See identical proteins and their annotated locations for NP_035315.1

    Status: PROVISIONAL

    Source sequence(s)
    AK132161
    Consensus CDS
    CCDS28411.1
    UniProtKB/Swiss-Prot
    O09061, Q62038, Q62039
    UniProtKB/TrEMBL
    Q6RI64
    Related
    ENSMUSP00000014913.9, ENSMUST00000014913.11
    Conserved Domains (2) summary
    COG0638
    Location:18240
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03757
    Location:29240
    proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    15695983..15718538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)