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Psma3 proteasome (prosome, macropain) subunit, alpha type 3 [ Mus musculus (house mouse) ]

Gene ID: 19167, updated on 8-Jul-2018
Official Symbol
Psma3provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, alpha type 3provided by MGI
Primary source
MGI:MGI:104883
See related
Ensembl:ENSMUSG00000060073 Vega:OTTMUSG00000035110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmpc8
Expression
Ubiquitous expression in placenta adult (RPKM 35.7), CNS E11.5 (RPKM 28.9) and 25 other tissues See more
Orthologs
See Psma3 in Genome Data Viewer
Location:
12; 12 C2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (70969413..70995877)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (72075610..72095924)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene ARP10 actin-related protein 10 Neighboring gene nuclear encoded tRNA lysine 17 (anticodon CTT) Neighboring gene RIKEN cDNA 3110056K07 gene Neighboring gene AT rich interactive domain 4A (RBP1-like) Neighboring gene translocase of outer mitochondrial membrane 20-like Neighboring gene predicted gene, 32906

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
proteasome complex ISO
Inferred from Sequence Orthology
more info
 
proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
proteasome subunit alpha type-3
Names
macropain subunit C8
multicatalytic endopeptidase complex subunit C8
proteasome component C8
proteasome subunit K
NP_001297524.1
NP_001297525.1
NP_035314.3
XP_017170485.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310595.1NP_001297524.1  proteasome subunit alpha type-3 isoform b

    See identical proteins and their annotated locations for NP_001297524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC132325, AI303320, AK169577, BY159585
    Consensus CDS
    CCDS79119.1
    UniProtKB/TrEMBL
    E0CX62, Q3TEL1
    Related
    ENSMUSP00000124894.2, OTTMUSP00000048802, ENSMUST00000160864.7, OTTMUST00000089319
    Conserved Domains (1) summary
    cl00467
    Location:1142
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_001310596.1NP_001297525.1  proteasome subunit alpha type-3 isoform b

    See identical proteins and their annotated locations for NP_001297525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC132325
    Consensus CDS
    CCDS79119.1
    UniProtKB/TrEMBL
    E0CX62
    Conserved Domains (1) summary
    cl00467
    Location:1142
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  3. NM_011184.5NP_035314.3  proteasome subunit alpha type-3 isoform a

    See identical proteins and their annotated locations for NP_035314.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC132325, AI303320, AK168495, BY159585
    Consensus CDS
    CCDS25961.1
    UniProtKB/Swiss-Prot
    O70435
    UniProtKB/TrEMBL
    Q58EV4
    Related
    ENSMUSP00000125548.1, OTTMUSP00000048799, ENSMUST00000160027.7, OTTMUST00000089313
    Conserved Domains (1) summary
    cd03751
    Location:5217
    proteasome_alpha_type_3; proteasome_alpha_type_3. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    70969413..70995877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314996.1XP_017170485.1  proteasome subunit alpha type-3 isoform X1

    UniProtKB/Swiss-Prot
    O70435
    UniProtKB/TrEMBL
    Q58EV4
    Conserved Domains (1) summary
    cd03751
    Location:5217
    proteasome_alpha_type_3; proteasome_alpha_type_3. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
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