U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Psma3 proteasome subunit alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 19167, updated on 11-Apr-2024

Summary

Official Symbol
Psma3provided by MGI
Official Full Name
proteasome subunit alpha 3provided by MGI
Primary source
MGI:MGI:104883
See related
Ensembl:ENSMUSG00000060073 AllianceGenome:MGI:104883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmpc8
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasomal protein catabolic process and regulation of endopeptidase activity. Part of proteasome core complex. Is expressed in several structures, including alimentary system; central nervous system; cranium; dorsal root ganglion; and lung. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 35.7), CNS E11.5 (RPKM 28.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
12 C2; 12 29.39 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71016082..71042651)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70969283..70995877)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8488 Neighboring gene ARP10 actin-related protein 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72069569-72069678 Neighboring gene STARR-positive B cell enhancer ABC_E1441 Neighboring gene STARR-positive B cell enhancer ABC_E7144 Neighboring gene STARR-positive B cell enhancer ABC_E1442 Neighboring gene nuclear encoded tRNA lysine 17 (anticodon CTT) Neighboring gene RIKEN cDNA 3110056K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E11778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116322-72116431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116588-72116697 Neighboring gene AT-rich interaction domain 4A Neighboring gene STARR-seq mESC enhancer starr_32414 Neighboring gene STARR-positive B cell enhancer ABC_E7145 Neighboring gene STARR-seq mESC enhancer starr_32415 Neighboring gene translocase of outer mitochondrial membrane 20-like Neighboring gene predicted gene, 32906

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-3
Names
macropain subunit C8
multicatalytic endopeptidase complex subunit C8
proteasome (prosome, macropain) subunit, alpha type 3
proteasome component C8
proteasome subunit K
NP_001297524.1
NP_001297525.1
NP_001409967.1
NP_001409969.1
NP_001409970.1
NP_001409971.1
NP_001409974.1
NP_035314.3
XP_036013150.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310595.1NP_001297524.1  proteasome subunit alpha type-3 isoform b

    See identical proteins and their annotated locations for NP_001297524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC132325, AI303320, AK169577, BY159585
    Consensus CDS
    CCDS79119.1
    UniProtKB/TrEMBL
    E0CX62, Q3TEL1
    Conserved Domains (1) summary
    cl00467
    Location:1142
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_001310596.1NP_001297525.1  proteasome subunit alpha type-3 isoform b

    See identical proteins and their annotated locations for NP_001297525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC132325
    Consensus CDS
    CCDS79119.1
    UniProtKB/TrEMBL
    E0CX62, Q3TEL1
    Conserved Domains (1) summary
    cl00467
    Location:1142
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  3. NM_001423038.1NP_001409967.1  proteasome subunit alpha type-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC132325
    UniProtKB/Swiss-Prot
    O70435
    UniProtKB/TrEMBL
    Q58EV4
  4. NM_001423040.1NP_001409969.1  proteasome subunit alpha type-3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC132325
    UniProtKB/TrEMBL
    E0CX62
  5. NM_001423041.1NP_001409970.1  proteasome subunit alpha type-3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC132325
  6. NM_001423042.1NP_001409971.1  proteasome subunit alpha type-3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC132325
  7. NM_001423045.1NP_001409974.1  proteasome subunit alpha type-3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC132325
    UniProtKB/Swiss-Prot
    O70435
    UniProtKB/TrEMBL
    Q58EV4
  8. NM_011184.5NP_035314.3  proteasome subunit alpha type-3 isoform a

    See identical proteins and their annotated locations for NP_035314.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC132325, AI303320, AK168495, BY159585
    Consensus CDS
    CCDS25961.1
    UniProtKB/Swiss-Prot
    O70435
    UniProtKB/TrEMBL
    Q58EV4, Q9DCD8
    Related
    ENSMUSP00000125548.2, ENSMUST00000160027.8
    Conserved Domains (1) summary
    cd03751
    Location:5217
    proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    71016082..71042651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157257.1XP_036013150.1  proteasome subunit alpha type-3 isoform X2

    UniProtKB/TrEMBL
    Q9DCD8
    Conserved Domains (1) summary
    cd03751
    Location:5195
    proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...